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Zusatztext 'Rainsford and co-writers do a superb job in detailing much of these lesser well-known actions of aspirin. The clinical studies with aspirin are presented exceptionally well and in great detail. The references following each chapter are the most comprehensive that I have seen. Parts of this book will find a very wide audience. Clinicians who use aspirin and related drugs should read some of the clinical chapters to see how little they know about the drugs they use. Research workers will find much here of interest! especially those with their heart in the right place who query prevailing dogmas. I would certainly have benefited from this book at the beginning of my research carrier and I would urge any and all PhD students working with anti-inflammatory drugs to dive into relevant chapters.'- Professor Ingvar Bjarnason! Professor of Digestive Diseases in the Department of Medicine! King's College London! for Journal of Pharmacy and Pharmacology! Volume 58! Issue 12! Page 1691! December 2006. Informationen zum Autor Kim D. Rainsford Klappentext This much anticipated volume reviews over a century of aspirin research and use. Providing a comprehensive source of information on the history! chemistry! absorption in the body! therapeutic effects! toxicology! elimination! and future uses of aspirin! it is the most definitive reference currently available. Aspirin and Related Drugs includes the commercial use of aspirin and outlines the chemical properties and synthesis of aspirin and its derivatives developed over the last 100 years. Physicians! pharmacists! pharmacologists! toxicologists! and chemists will find this definitive reference an invaluable insight into this popular and fascinating drug. Zusammenfassung Reviews over a century of aspirin research and use. This work provides information on the history, chemistry, absorption in the body, therapeutic effects, toxicology, elimination, and future uses of aspirin. It includes the commercial use of aspirin and outlines the chemical properties and synthesis of aspirin and its derivatives. Inhaltsverzeichnis History and Development of the Salicylates. The Industrial History of Analgesics: The Evolution of Analgesics and Antipyretics. Occurrence! Properties and Synthetic Developments of the Salicylates. Pharmacokinetics and Metabolism of the Salicylates. Metabolism and Pharmacokinetics of Ibuprofen. Pharmacokinetics and Metabolism of Paracetamol (Acetaminophen). Pharmacology and Biochemistry of Salicylates and Related Drugs. Side-effects and Toxicology of the Salicylates. Reye's Syndrome and Aspirin. Salicylates in the Treatment of Acute Pain. Acetysalicylic Acid for the Prevention and Treatment of Thromboembolic Diseases. Use of Salicylates in Rheumatic and Related Conditions. Aspirin and NSAIDs in the Prevention of Cancer! Alzheimer's Disease and other Novel Therapeutic Actions. ...
