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The announcement that we had decoded the human genome in 2000 ushered in a new and unique era in biomedical research and clinical medicine. This Third Edition of Principles of Gender-Specific Medicine focuses, as in the past two editions, on the essentials of sexual dimorphism in human physiology and pathophysiology, but emphasizes the latest information about molecular biology and genomic science in a variety of disciplines. Thus, this edition is a departure from the previous two; the editor solicited individual manuscripts from innovative scientists in a variety of fields rather than the traditional arrangement of sections devoted to the various subspecialties of medicine edited by section chiefs. Wherever it was available, these authors incorporated the latest information about the impact of the genome and the elements that modify its expression on human physiology and illness. All chapters progress translationally from basic science to the clinical applications of gender-specific therapy and suggest the most important topics for future investigation. This book is essential reading for all biomedical investigators and medical educators involved in gender-specific medicine. It will also be useful for primary care practitioners who need information about the importance of sex and gender in the prevention, diagnosis and treatment of illness.
Sommario
1. Normal and variant sex development
2. Gender DiagnosesJack Drescher
3. Gender Identity in Disorders of Sex Development
4. Female sexual function: the role of animal models in assessing female sexual dysfunction
5. Fertility Treatment and Preservation in Transgender Men and Women
6. Standards of Care for the Health of Transsexual, Transgender and Gender-Nonconforming People: An Introduction
7. Sex-dependent and -independent Mechanisms in External Genitalia Development
8. The Transsexual Adult
9. Sexual and gender minority individuals in health care: strategies to include sexual orientation and gender identity in health professions education
10. Sex Influences Exist at All Levels of Human Brain Function
11. Sex differences in the brain: Focus on developmental mechanisms
12. Sexual dimorphisms in the nervous system of the nematode Caenorhabditis elegans
13. Oxytocin and Brain Plasticity
14. Emotion and Gender-specific neural processing in men and women
15. Behind the Mask: the experience of assessment, diagnosis and living with autism for girls and young women
16. The significance of gender in perinatal medicine
17. Intrauterine Development of Sex Differences - Fetal Programming
18. Battle of the sexes: How the selection of spermatozoa in the female reproductive tract manipulates the sex ratio of offspring
19. All Cells have a sex: Studies of sex chromosome function at the cellular level
20. Sex-specific implications of exposure to an adverse intrauterine environment
21. Immune response - Impact of biological sex and gender
22. Geoepidemiology and the Impact of Sex on Autoimmune Diseases
23. Gender and gene regulation in human immunity
24. Sex and gender specific aspects - from cells to cardiovascular disease
25. Estrogen: Impact on Cardiomyocytes and the Heart
26. The Sexually Dimorphic Characteristics of the Pathophysiology and Treatment of Atrial Fibrillation
27. Gender Differences in Chronic Obstructive Pulmonary Disease- Current Knowledge and Deficits
28. Cancer: Gender differences at the molecular level
29. An Updated Overview of the Gender-Specific Response to Infection
30. Gender Based Differences in Mortality in Indian Children Aged 5 to 14 years
31. Consideration of biological sex in translating regenerative stem cell therapies
32. Adipose-derived Stem Cells in Regenerative Medicine
33. Sex, Gender and Pain
34. Sex and gender differences in trauma victims presenting for treatment
35. Women Do Worse Than Men - Gender-Specific Differences in Burn Patients
36. Exercise physiology in Men & Women
37. Musculoskeletal complaints in male and female instrumental musicians
38. Nutritional Genomics and Biological Sex
39. Microbiome: Impact of gender on function & characteristics of gut microbiome
40. Sex and Gender Differences in Sleep Disorders: An Overview
41. Gender differences in bladder and kidney cancers
42. The complex challenge of blood pressure regulation: influences of sex and aging on sympathetic mechanisms
43. Gender at the Interface of Renal Aging: Physiological and Pathological Perspectives
44. Gender differences in mobility of elderly: Measurements and interventions to improve mobility
45. Personalized Medicine in Space Flight, Part I: The Space Context and Standard Clinical Approaches
46. Personalized Medicine in Space Flight, Part II: Personalized Precision Medicine Approaches
47. Robots and Gender
48. Cyborgs: Understanding and Mutual Treatment
49. Personalized Medicine and Challenges in Research and Clinical Implementation
50. Biological Sex Differences in Humans and their Importance in Pharmaceutical Drug Discovery and Development
Info autore
Dr. Marianne Legato, Emerita Professor of Clinical Medicine at Columbia University, is an internationally known academic physician, author, lecturer, and specialist in gender-specific medicine. She is founding member of the International Society for Gender Medicine and the founder and director of The Partnership for Gender-Specific Medicine at Columbia University and its next iteration, The Foundation for Gender-Specific Medicine. She has published extensively on gender and sex specific medicine, both for the scientific community and for the lay public. She is also the founding editor of the Journal Gender Medicine, and the journal Gender and the Genome. In 1992, Dr. Legato won the American Heart Association’s Blakeslee Award for the best book written for the lay public on cardiovascular disease. The third edition of her textbook, Principles of Gender-Specific Medicine and her most recent book, The Plasticity of Sex., both won Prose awards from the American Association of Editors in 2021 and 2022 respectively. She is a practicing internist in New York City and has been listed each year in New York Magazine and Castle Connolly’s lists "Best Doctors" since their inception in 1993.
