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Developing the second edition of Neural Development and Stem Cells was neces- tated by the rapid increase in our knowledge of the development of the nervous system. It has become increasingly clear that stem cells are a heterogeneous population that changes extensively during development. Perhaps the most important advance in our understanding of stem cell behavior has been the realization that regionalization of stem cells occurs early in development and this bias toward differentiation in phe- types of neurons or cells characteristic of a particular part of the brain appears to persist even after prolonged culture. We have therefore included additional chapters on olf- tory epithelial stem cells and retinal stem cells, both of which differ in their properties from ventricular zone and subventricular zone-derived neural stem cells. It is also now clear from an analysis of mutants and transgenics where the death or self-renewal pa- way is altered that cell death regulates stem cell number. As a consequence, this second edition includes a separate chapter on cell death that summarizes the important changes in the death pathway that occur as stem cells mature. The existing chapters in the book have also been extensively revised and updated by experts who have generously c- tributed their time and expertise. The chapters have been organized along the lines of our understanding of how the nervous system develops (Fig. 1, on p. vi).
Sommario
"Defining Neural Stem Cells and Their Role in Normal Development of the Nervous System
Sally Temple
Neural Stem Cells in the Adult Brain: Implications of Their Glial Characteristics
Daniel A. Lim and Arturo Alvarez-Buylla
Cellular and Molecular Properties of Multipotent Neural Stem Cells Throughout Ontogeny
Larysa Halyna Pevny
Multipotent Stem Cells in the Embryonic Nervous System
Ali Jalali, Michael Bonaguidi, Caitilin Hamill, and John A. Kessler
Regulation of Neural Stem Cell Death
Rizwan S. Akhtar and Kevin A. Roth
Neuronal Progenitor Cells of the Mammalian Neonatal Anterior Subventricular Zone
Douglas L. Falls and Marla B. Luskin
Glial Restricted Precursors
Mark Noble and Margot Mayer-Pröschel
PNS Precursor Cells in Development and Cancer
Houman D. Hemmati, Tanya A. Moreno, and Marianne Bronner-Fraser
Stem Cells of the Adult Olfactory Epithelium
James E. Schwob and Woochan Jang
Retinal Stem Cells
Ani V. Das, Jackson James, Sreekumaran Edakkot, and Iqbal Ahmad
Transdifferentiation in the Nervous System
Ying Liu and Mahendra S. Rao
Neural Progenitor Cells of the Adult Human Brain
Steven A. Goldman
Embryonic Stem Cells and Neurogenesis
Robin L. Wesselschmidt and John W. McDonald
Mobilizing of Neural Precursors in the Adult Central Nervous System
Theo D. Palmer and Fred H. Gage
Neural Stem Cells and Transplant Therapy: Intrinsic Programs and Clinical Applications
Jaime Imitola, Yang D. Teng, Vaclav Ourednik, Kook In Park, Richard L. Sidman, and Evan Y. Snyder
Appendix A: Neural Stem Cell Companies
Appendix B: Stem Cells and Transplants
Appendix C: Patents and Stem Cells
Appendix D: Stem Cells and US Federal Guidelines
Index"
