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Klappentext An invaluable book containing a series of interdisciplinary discussions between clinical and basic scientists. Biology of IGF-1: Its interaction with insulin and health and malignant states focuses on key issues such as:* the definition of danger zones* the development of methods for early recognition of malignant states linked to IGF-1 and/or insulin* possible approaches to preventative intervention* the relevance in this field of research to the development of novel therapeutic approaches to treating certain cancers. Zusammenfassung An invaluable book containing a series of interdisciplinary discussions between clinical and basic scientists. Biology of IGF-1: Its interaction with insulin and health and malignant states focuses on key issues such as:* the definition of danger zones* the development of methods for early recognition of malignant states linked to IGF-1 and/or insulin* possible approaches to preventative intervention* the relevance in this field of research to the development of novel therapeutic approaches to treating certain cancers. Inhaltsverzeichnis Chair's Introduction (Leroith).Circulating IGF-I and its role in cancer: lessons from the IGF-1 gene-deletion (LID) mouse (Yakar et al).Physiology of the IGF system (Holly).Molecular basis of insulin action (Zick).IGF-1 and insulin as growth hormones (Laron).Insulin-like growth factors and neoplasia (Pollak).Loss of IGF2 imprinting: mechanisms and consequences (Ohlsson).Insulin and IGF-1 receptor trafficking and sginalling (Foti et al).The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb (Nobukini and Thomas).Structural biology of insulin and IGF-1 receptors (De Meyts et al).Genetic blockade of the insulin-like growth factor-I receptor for human malignancy (Adachi et al).IGF-1 and prostate cancer (Roberts Jr.).IGF-1 and breast cancer (Lonning and Helle).IGFBPs and cancer (Fang et al).The IGF receptor as anti-cancer treatment target (Macaulay).Nutrition, insulin, IGF-1 metabolism and cancer risk: a summary of epidemiological evidence (Kaaks).Final discussion.Index of contributors.Subject index....
Sommario
Chair's Introduction (Leroith).Circulating IGF-I and its role in cancer: lessons from the IGF-1 gene-deletion (LID) mouse (Yakar et al).Physiology of the IGF system (Holly).Molecular basis of insulin action (Zick).IGF-1 and insulin as growth hormones (Laron).Insulin-like growth factors and neoplasia (Pollak).Loss of IGF2 imprinting: mechanisms and consequences (Ohlsson).Insulin and IGF-1 receptor trafficking and sginalling (Foti et al).The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb (Nobukini and Thomas).Structural biology of insulin and IGF-1 receptors (De Meyts et al).Genetic blockade of the insulin-like growth factor-I receptor for human malignancy (Adachi et al).IGF-1 and prostate cancer (Roberts Jr.).IGF-1 and breast cancer (Lonning and Helle).IGFBPs and cancer (Fang et al).The IGF receptor as anti-cancer treatment target (Macaulay).Nutrition, insulin, IGF-1 metabolism and cancer risk: a summary of epidemiological evidence (Kaaks).Final discussion.Index of contributors.Subject index.
