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In this issue of Clinics in Liver Disease, guest editor Dr. Nikolaos T. Pyrsopoulos brings his considerable expertise to the topic of Acute-on-Chronic Liver Failure. Recent studies indicate that as many as one in four patients with cirrhosis develop acute-on-chronic liver failure (ACLF) and 25% die within one month. This issue, the first devoted to this topic, provides thorough coverage of critical clinical interventions, including diagnosis, treatment, and management. It also focuses on early recognition of ACLF, which is important for the initiation of aggressive management and ultimately, saving lives.
- Contains 17 practice-oriented topics including ACLF: mechanisms of disease and multisystemic involvement; the clinical spectrum and manifestations of ACLF; management of ACLF; maximizing the donor potential for patients with ACLF Listed for Liver Transplant; future approaches and therapeutic modalities for ACLF; and more.
- Provides in-depth clinical reviews of acute-on-chronic liver failure, offering actionable insights for clinical practice.
- Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Sommario
Classification and Epidemiologic Aspects of Acute-on-Chronic Liver Failure Mechanisms of Disease and Multisystemic Involvement Pathology of Acute and Acute-on-Chronic Liver Failure Liver Regeneration in Acute-on-Chronic Liver Failure Viral Hepatitis and Acute-on-Chronic Liver Failure Drug-Induced Acute-on-Chronic Liver Failure: Challenges and Future Directions Nonviral or Drug-Induced Etiologies of Acute-on-Chronic Liver Failure (Autoimmune, Vascular, and Malignant) Acute-on-Chronic Liver Failure in Patients with Alcohol-Associated Hepatitis: A Review The Clinical Spectrum and Manifestations of Acute-on-Chronic Liver Failure Prognostic Models in Acute-on-Chronic Liver Failure Hepatic Encephalopathy in Acute-on-Chronic Liver Failure Bacterial Infections in Acute-on-Chronic Liver Failure Management of Portal Hypertension in Patients with Acute-on-Chronic Liver Disease Liver Transplantation in Acute-on-Chronic Liver Failure Maximizing the Donor Potential for Patients with Acute-on-Chronic Liver Failure Listed for Liver Transplant Future Approaches and Therapeutic Modalities for Acute-on-Chronic Liver Failure
