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The work presents a modern understanding of molecular and biochemical mechanisms of physiological pregnancy disorders that lead to complications during gestation and childbirth, including premature births. The role of impaired nitroxidergic and thiol-disulfide systems was described for the first time. For the first time, the role of protein-chaperones (HSP70) in providing mechanisms of endogenous cytoprotection, regulating mechanisms of adaptation to hypoxia, was demonstrated. The role of estrogens in the regulation of pregnancy and endogenous neuro- and cytoprotection has been clarified. Mechanisms of initiation of stress in pregnant women and post-stressor mechanisms leading to complications of pregnancy and childbirth were described. The possibility of using metabolitotropic therapy in pregnant women with a threat of premature birth has been substantiated, as well as multivariate models for predicting premature birth and their threats have been developed and proposed.
Info autore
Kyryliuk Alexander D.Candidate of Medical Sciences.Director of a municipal non-profit enterprise «Regional Perinatal Center» of the Zaporizhzhia Regional Council.Belenichev Ihor F.Doctor habil of Bsology and Medicine, Full Professor Head of the Department. Pharmacology and Medical Formulation with Course of Normal Physiology
