Introductory Immunology - Basic Concepts for Interdisciplinary Applications

Revised edition of: Introductory immunology / Jeffrey K. Actor. Second edition. [2019].

Sommario

Preface
Acknowledgments
1. A functional overview of the immune system and components
Chapter focus
Immune homeostasis
Self versus nonself
Innate and adaptive immunity
Anatomy of the immune system
Cells of the immune system
First-line defenders: the myeloid cells
Adaptive avengers: the lymphoid cells
Lymphocytes
Cluster of differentiation
Summary
2. The inflammatory response
Chapter focus
Inflammation
Initiation of the inflammatory response
The role of antibodies in inflammation
Biological functions of complement
Activation and directed migration of leukocytes
Pathogen recognition and cytokine signaling
Feedback and adaptation from a distance
Pathological consequences of the inflammatory Response
Summary
3. The B lymphocyte: antibodies and how they function
Chapter focus
B lymphocytes produce antibodies
Structural characteristics of immunoglobulins
Immunoglobulin nomenclature
Biologic properties of antibody isotypes
IgD
IgM
IgG
IgA
IgE
Kinetics of antibody response
Membrane-bound immunoglobulin
Development of B cells
Antibody gene recombination
Development and selection of mature B cells
Activation and differentiation of B cells
Summary
4. T lymphocytes: ringleaders of adaptive immune function
Chapter focus
T lymphocytes: specific and long-lasting immunity
The T cell receptor
T-cell development
Antigen recognition by T cells: requirement of major histocompatibility molecules
The HLA locus
MHC class I
MHC class II
T lymphocyte functions
CD4 1 T-helper cells
Events involved in T lymphocyte activation
Role of T cells in B-cell activation
Cytotoxic T-cell effectors
CD8 1 T cells
Other lymphocyte phenotypes
¿¿ T cells
Innate lymphocytes
Natural killer T (NKT) cells
Superantigens
Summary
5. How we defend against infectious agents
Chapter focus
Immune homeostasis and pathogenic organisms
Major immune defense mechanisms against pathogens
Physical barriers to infection
Anatomic barrier
Physiological barrier
Phagocytic and endocytic barriers
Inflammatory barriers
Bacterial infections
Microbial motifs detected through pattern-recognition receptors
Mycobacterial infections
Viral infections
Human immunodeficiency virus
Parasitic infections (helminths)
Fungal infections
Evasion of immune response
Summary
6. Basic disorders of immune function
Chapter focus
Immunodeficiency disorders
Genetic basis for primary immunodeficiency
Innate deficiencies
Chronic granulomatous disease/myeloperoxidase deficiency
Leukocyte adhesion deficiency
ChediakComplement disorders
Innate pattern-recognition receptor disorders
Adaptive immune disorders
X-linked agammaglobulinemia
Selective immunoglobulin A deficiency
Common variable immunodeficiency
Hyper immunoglobulin M disorders
DiGeorge syndrome
WiskottSevere combined immunodeficiency
Treatment of immunodeficiency diseases
Immunodeficiency as a predisposition to disease
Human immunodeficiency virus and acquired immunodeficiency syndrome
Summary
7. Autoimmunity: regulation of response to self
Chapter focus
Homeostasis, immune regulation, and autoimmunity
Tolerance to self
Etiology of autoimmune disease
Role of autoantibodies and self-reactive T lymphocytes in autoimmune disorders
Laboratory tests for autoimmunity
Targeted therapeutics
Summary
8. Immune hypersensitivities
Chapter focus
Hypersensitive disorders
Type I hypersensitivity: immunoglobulin EType II hypersensitivity: antibody-mediated cytotoxic hypersensitivity
Type III hypersensitivity: immune complex-mediated hypersensitivity
Type IV hypersensitivity: delayed-type (cell-mediated) hypersensitivity
Alternative hypersensitivity classifications
Summary
9. Vaccines and immunotherapy
Chapter focus
Principles of vaccination
Basic concepts of protective immunization
Types of immunizations
Age and timing of immunizations
Vaccine types and components
Immunologic adjuvants
Passive immunization
Therapeutic uses of immunoglobulins
Other ways to modify immunity
Summary
10. Cancer immunology
Chapter focus
Understanding immune defenses against cancers
Tumor antigens
Effector mechanisms in tumor immunity
Natural killer cells and innate response to tumor cells
Adaptive response to tumor cells
Escape mechanisms of tumor elimination
Tumors of the immune system
Immunodiagnosis and immunotherapy
Summary
11. Transplantation immunology
Chapter focus
Transplantation defined
Tissue histocompatibility
Natural isohemagglutinins
Human leukocyte antigens
Allograft rejection
Hyperacute rejection
Accelerated rejection
Acute rejection
Chronic rejection
Graft-versus-host disease
Pretransplantation histocompatibility evaluation
Immunosuppressive drugs to prevent allograft rejection
Immunosuppressive therapy
Summary
12. Assessment of immune parameters and immunodiagnostics
Chapter focus
AntibodyAffinity
Secondary manifestations of antibodySolid-phase precipitation assays
Radial immunodiffusion
The Ouchterlony assay
Immunoelectrophoresis
Latex agglutination
Lateral flow
Western blot
Immunoassays
Enzyme-linked immunoadsorbent assay
Detection of cellular antigens
Immunohistochemistry
Fluorescence-activated cell sorting analysis
Multiplex bead arrays
Assays to determine immune function
Complement fixation test
Phagocyte function assays
Lymphocyte function assays
Other tools to measure immunological status
Monoclonal antibodies
Microarrays
Summary
Glossary
Index

Info autore

Jeffrey K. Actor, PhD, is a professor and Medical Immunology Course Director in the Department of Pathology and Laboratory Medicine at the McGovern Medical School at the University of Texas Health Center at Houston. Dr. Actor received his PhD degree from the University of Massachusetts. His research interests include examination of host immune responses during pathogenic disease, understanding proinflammatory and regulatory cytokines during mycobacterial infections, vaccine development, and molecular mechanisms of adjuvant-induced immunomodulation.

Professor Actor has established himself as a productive educator-scientist with a strong background in immunology and molecular biology with a broad range of expertise in pathobiology. He has shown his commitment to education and excellence, at both the Medical School and Graduate School levels.

Dettagli sul prodotto

• Autori: Jeffrey Actor, Jeffrey K Actor, Jeffrey K. Actor
• Editore: Academic Press London
• Lingue: Inglese
• Formato: Tascabile
• Pubblicazione: 01.02.2023
• EAN: 9780443153075
• ISBN: 978-0-443-15307-5
• Pagine: 200
• Categorie: Scienze naturali, medicina, informatica, tecnica > Medicina > Farmacia; Immunology, MEDICAL / Immunology, MEDICAL / Pharmacology, Pharmacology