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Understanding the nature and role of endothelium-derived hyperpolarizing factor is crucial in the quest for improved treatments for hypertension, diabetes, ischemia-reperfusion, and other vascular disorders. The book focus on the role of gap junctions in cardiovascular responses and investigate the chemical identity of EDHF. EDHF 2000 will be of interest not only to physiologists and pharmacologists puzzled by the complexity of the interactions between the endothelium and underlying vascular smooth muscle cells, but also clinical researchers and physicians treating patients with cardiovascular diseases.
Sommario
1. What do gap junctions do anyway? 2. Cardiovascular gap junctions: Functional Diversity, complementation and specialization of connexins 3. Endothelium and smooth muscle pathways for conduction along resistance microvessels 4. Membrane potential and calcium responses evoked by acetylcholine in submucosal arterioles of the guinea-pig small intestine 5. The effects of ouabain, 18a-glycyrrhetinic acid and connexin-mimetic peptides on intercellular communication in cells expressing a
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Paul M. Vanhoutte
Riassunto
On the subject of endothelium-dependent hyperpolarizations, this volume focuses upon the role of gap junctions in cardiovascular responses and investigates the chemical identity of EDHF. Additional chapters on physiology, hormonal modulation and pathological changes are also included.
