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This book focuses on C-type lectin receptors, a newly emerging family of pattern-recognition receptors (PRRs) and a crucial part of the human innate immune system. Above all, the authors highlight these receptors' role in the recognition of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) - one of the first steps in responding to foreign and potentially dangerous structures in the human body.
The respective chapters chiefly examine various C-type lectin receptors, their corresponding ligands, and signalling. In addition to offering immunologists and clinicians important insights from the latest research, they may also provide novel points of departure for future drug development.
Sommario
C-type lectin receptors in phagocytosis.- C-type lectins in immunity to lung pathogens.- Signalling C-type lectins in antifungal immunity.- Dendritic cell immunoactivating receptor: an activating receptor for mycobacteria.- myeloid C-type lectin receptors sensing tissue damage.- 3D structure and ligand recognition of C-type lectins.- Mechanisms and Functions of CARD9 Signaling in the Innate Immune System.
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Sho Yamasaki is Distinguished Professor at Osaka University and the head of the division Molecular Immunology at the Research Institute for Microbial Diseases (RIMD) and deputy director of Immunology Frontier Research Center (IFReC) in Osaka University. He is also the visiting professor at Kyushu University and Chiba University. His laboratory focuses on understanding the molecular mechanisms underlying the recognition of external and internal insults through ITAM-coupled immune receptors. Of particular interest is the regulation of immune responses against pathogens and altered self through C-type lectin receptors and T cell receptors.
