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The Chlamydomonas Sourcebook, 3rd Edition Cell Motility and Behavior (Volume 3) The gold-standard reference introducing this multidisciplinary science, fully revised and updated with the latest discoveries Originally published as the standalone Chlamydomonas Sourcebook, then expanded as the third volume in a three-part comprehensive gold-standard reference, The Chlamydomonas Sourcebook: Cell Motility and Behavior has been fully revised and updated to include the wealth of new resources for the Chlamydomonas community. Reflecting the significant advancement in the understanding of the role of basal bodies and cilia play in human diseases, this volume employs quantitative proteomics and mass spectroscopy as well as cryo EM tomography and single particle cryo EM. Other topics such as current insights on mitosis and cytokinesis, ciliary assembly and motility, intraflagellar transport, and more help build an understanding of human diseases of the cilium. Cell Motility and Behavior presents the latest in research and best practices, making this a must-have resource for researchers and students working in plant science and photosynthesis, fertility, mammalian vision, and biochemistry; crop scientists; plant physiologists; and plant, molecular, and human disease biologists.
Sommario
1. Landmark Contributions of Chlamydomonas to Understanding Cilia
2. Basal bodies
3. Transition Zone
4. Dynein
5. Axonemal Dynein Preassembly
6. Ciliary Radial Spokes
7. Central pair
8. N-DRC
9. MIPS
10. Asymmetries
11. The Chlamydomonas ciliary membrane and its dynamic properties
12. Physics and mechanics of ciliary beating
13. IFT
14. Length control
15. Ciliary Disassembly
16. Deciliation
17. The Eyespot and Behavioral Light Responses
18. Ciliary adhesion and cilium-generated signaling during fertilization
19. Cytoskeleton
Info autore
Susan?K. Dutcher?is a professor and the former director of the McDonnell Genome Institute at?Washington University School of Medicine.?She earned her PhD at the University of Washington in Seattle, where her thesis work focused on the role of cell division cycle genes in karyogamy in S. cerevisiae with Dr. Leland Hartwell. In 1980, she began work on Chlamydomonas basal bodies and cilia at Rockefeller University. She was a faculty member at the University of Colorado, Boulder from 1983 to 1999. Her?lab investigates the assembly and function of basal bodies/centrioles and cilia using genetics, biochemistry, microscopy, and computational biology in?Chlamydomonas?as well as human tissue culture cells.?Key questions addressed in her research are how these microtubule-based structures are assembled, how they are regulated with respect to the cell cycle, and how they function and influence cellular biology, development, and human health.?Stemming from the lab’s comparative genomics work in 2004, the discovery of many cilia and centriole-based diseases has illustrated the incredible breath of roles that these organelles play in human health. She is a fellow of the American Academy of Arts and Sciences, the American Society of Cell Biology, and the American Association for the Advancement of Science. She has had key collaborations with numerous scientists.
