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Translational Autoimmunity: Etiology of Autoimmune Diseases is the first volume of the Translational Immunology book series. To attain its purpose as a detailed translational step to tackle autoimmunity, this volume sufficiently addresses basic questions on how the immune system is designed to distinguish self from nonself. It discusses the known mechanisms that lead to the maintenance of self-tolerance, presents potential triggers and malfunctions that impede normal immune processes, and demonstrates how the immune system induces an autoreactive state that results in the recognition of self-antigens seen in autoimmune conditions.
Sommario
1. Introduction on translational autoimmunity: From bench to bedside
2. Autophagy in autoimmunity
3. Immunometabolism and autoimmunity
4. T cell recognition of neo-epitopes in autoimmunity
5. Role of Th1 and Th2 in autoimmunity
6. Role of Th17 cell in tissue inflammation and organ-specific autoimmunity
7. Peptide editing and its modulation in CD4+ T cell immune tolerance
8. Innate lymphoid cells (ILCs) in the immunopathogenesis of autoimmune diseases
9. Autoimmune diseases and the role of toll-like receptor-7 and -9 signaling cascades
10. Association between type III interferons and systemic autoimmune diseases
11. Regulation of immunological tolerance by NF-kB
12. Micro RNA, circular RNA, neutrophils and myeloperoxydases in autoimmune diseases
13. Human leukocyte antigen and autoimmunity
14. HLA-G-mediated immunological tolerance and autoimmunity
15. The immune system and the microbiota: the two sides of mucosal tolerance
16. Role of free radicals in autoimmune disorders
17. Immunological tolerance and autoimmunity
18. Construction of bioscore for sprouting of self-tolerance failure: From analysis of silicosis cases
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Professor Nima Rezaei gained his medical degree (MD) from Tehran University of Medical Sciences and subsequently obtained an MSc in Molecular and Genetic Medicine and a PhD in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also spent a short-term fellowship of Pediatric Clinical Immunology and Bone Marrow Transplantation in the Newcastle General Hospital. Professor Rezaei is now the Full Professor of Immunology and Vice Dean of Research, School of Medicine, Tehran University of Medical Sciences, and the co-founder and Head of the Research Center for Immunodeficiencies. He is also the founding President of the Universal Scientific Education and Research Network (USERN). Professor Rezaei has already been the Director of more than 55 research projects and has designed and participated in several international collaborative projects. Professor Rezaei is an editorial assistant or board member for more than 30 international journals. He has edited more than 35 international books, has presented more than 500 lectures/posters in congresses/meetings, and has published more than 1,000 scientific papers in the international journals.
