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The first International Conference on Oral Mucosal Immunity and Microbiome (OMIM) aimed to highlight cutting-edge basic and translational research from an oral immunological and microbiological perspective. Oral diseases with a microbial etiology are the most prevalent chronic diseases of humans. Whilst not life-threatening, they can significantly compromise quality of life, are associated with increased risk for certain systemic diseases, and pose heavy financial burdens to national health systems. Hence, periodontal and peri-implant diseases, dental caries, root canal infections and mucosal infections are significant global public health problems.
In this book global experts summarize and discuss the latest progress made in oral mucosal immunity and the oral microbiome. Target audience is basic and/or translational researchers with expertise in host immunity and microbiome research, and interest in oral health and disease. This volume provides a much needed quantum leap in the field, by joining forces to address gaps at the oral mucosal immunity-microbiome cross-talk.
Sommario
1. Advances in oral mucosal immunity and the microbiome.- 2. Trained innate immunity and its implications for mucosal immunity and inflammation.- 3. Signaling systems in oral bacteria.- 4. Origin of Th17 cells in Type 2 Diabetes-Potentiated Periodontal Disease.- 5. Gingival epithelial cell recognition of lipopolysaccharide.- 6. The relationship of Candida albicans with the oral bacterial microbiome in health and disease.- 7. A potential role of Phospholipase 2 group IIA (PLA2-IIA) in P. gingivalis-induced oral dysbiosis.- 8. Helicobacter spp. in experimental models of colitis.- 9. T Helper 17 cells as pathogenic drivers of periodontitis.- 10. Candida-bacterial biofilms and host-microbe interactions in oral diseases.- 11. Comparative analysis of gene expression patterns for oral epithelium-related functions with aging.- 12. Neutrophil interaction with emerging oral pathogens: a novel view of the disease paradigm.- 13. Biologically-defined or biologically-informed traits are more heritable than clinically-defined ones: the case of oral and dental phenotypes.-
Info autore
Georgios N. Belibasakis
Karolinska Institute Department of Dental Medicine
Department of Dental Medicine
Huddinge
Stockholms Län
Sweden
Nagihan Bostanci
Karolinska Institute Department of Dental Medicine
Huddinge
Stockholms Län
Sweden
Michael A. Curtis
King's College London Dental Institute
London
United Kingdom
George Hajishengallis
Univ of Pennsylvania Penn Dental Med Microbio
Penn Dental Med Microbio
Philadelphia
Pennsylvania
USA
