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This book discusses various aspects of chiral fine chemicals including their synthesis and uses at scale. It also discusses how the key subclasses of the chiral pool are obtained and covers methods that can be used to introduce or control stereogenic centers.
Sommario
1. Introduction 2. Amino Acids 3. Microbial Pathway Engineering for Amino Acid Manufacture 4. Carbohydrates in Synthesis 5. Terpenes: The Expansion of the Chiral Pool 6. Resolutions at Large Scale: Case Studies 7. New Developments in Crystallization-Induced Resolution 8. The Role of cis-1-Amino-2-Indanol in Resolution Processes 9. Asymmetric Oxidations 10. Asymmetric Epoxidation of Olefins by Chiral Ketones 11. Ozonolysis in the Production of Chiral Fine Chemicals 12. Transition Metal Catalyzed Hydrogenations, Isomerizations, and Other Reactions 13. Modular, Chiral P-Heterocycles in Asymmetric Catalysis 14. Asymmetric Olefin Hydrogenation Using Monodentate BINOL- and Bisphenol-Based Ligands: Phosphonites, Phosphites, and Phosphoramidites 15. Asymmetric Catalytic Hydrogenation Reactions with Ferrocene-Based Diphosphine Ligands 16. Asymmetric Reduction of Prochiral Ketones Catalyzed by Oxazaborolidines 17. cis-1-Amino-2-Indanol-Derived Ligands in Asymmetric Catalysis 18. Enantioselective Hydrogenation of Activated Ketones Using Heterogeneous Pt Catalysts Modified with Cinchona Alkaloids 19. Biotransformations: “Green” Processes for the Synthesis of Chiral Fine Chemicals 20. Combining Enzyme Discovery and Evolution to Develop Biocatalysts 21. One-Pot Synthesis and the Integration of Chemical and Biocatalytic Conversions 22. Substitution Reactions 23. Industrial Applications of Chiral Auxiliaries 24. The Role and Importance of cis-1-Amino-2-Indanol in Biological Systems and Asymmetric Processes 25. Enantiopure Amines by Chirality Transfer Using (R)-Phenylglycine Amide 26. Pericyclic Reactions 27. Asymmetric Free-Radical Reductions Mediated by Chiral Stannanes, Germanes, and Silanes 28. Metathesis Reactions 29. Synthesis of Homochiral Compounds: A Small Company’s Role 30. Commercial Synthesis of the Antiglaucoma Prostanoid Travoprost 31. Synthesis of Large Volume Products
Info autore
David Ager
Riassunto
This book discusses various aspects of chiral fine chemicals including their synthesis and uses at scale. It also discusses how the key subclasses of the chiral pool are obtained and covers methods that can be used to introduce or control stereogenic centers.
