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This second edition provides detailed LC-MS(/MS) procedures for the analysis of compounds of clinical and toxicological significance. Chapters detail new and updated methods for analyzing drugs focusing on advances in technology, alternate matrices, and rapidly-changing classes of drugs of abuse, compounds pertinent to toxicology, and therapeutic agents. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and cutting-edge, LC-MS in Drug Analysis: Methods and Protocols, Second Edition aims to ensure successful reults in the further study of this vital field.
Sommario
An Introduction to Drug Testing - The Expanding Role of Mass Spectrometry.- Quantification of Eight Cannabinoids Including Cannabidiol in Human Urine Via Liquid Chromatography Tandem Mass Spectrometry.- Analysis of Benzodiazepines for Drug Facilitated Assaults and Abuse Settings (Urine).- Targeted Opioid Screening Assay for Pain Management Using High Resolution Mass Spectrometry.- Measurement of Buprenorphine and Norbuprenorphine in Urine.- Quantitation of Tapentadol by Liquid Chromatography - Tandem Mass Spectrometry.- Therapeutic Drug Monitoring of Lacosamide by LC-MS/MS.- LC-MS/MS method for the quantification of the Leflunomide metabolite, Teriflunomide, in Human Serum/Plasma.- Analysis of Tryptic Peptides from Therapeutic Monoclonal Antibodies using LC-MS/MS.- Quantification of Methotrexate in Human Serum and Plasma by Liquid Chromatography Tandem Mass Spectrometry.- Simultaneous Determination of Tacrolimus and Cyclosporine A in Whole Blood by Ultra-Fast LC-MS/MS.- Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS) Method to Quantify Gabapentin and Pregabalin in Urine.- The Evolving Landscape of Designer Drugs.- Analysis of Synthetic Cannabinoid Metabolites by Liquid Chromatography-Tandem Mass Spectrometry.- Quantification of Designer Opioids by Liquid Chromatography Tandem Mass Spectrometry.- Screening Analysis for Designer Stimulants by LC-MS/MS.- Drug Screening Using Liquid Chromatography Quadrupole Time of Flight (LC-QqTOF) Mass Spectrometry.- Alternate Matrices - Meconium, Cord Tissue, Hair, and Oral Fluid.- Salt-assisted Liquid-Liquid Extraction of Meconium for Analysis of Cocaine and Amphetamines by Liquid Chromatography-tandem Mass Spectrometry.- Detection of In Utero Cannabis Exposure in Umbilical Cord Tissue by A Sensitive Liquid Chromatography-Tandem Mass Spectrometry Method.- Quantitation of Ethyl beta-D-glucuronide in Human Umbilical Cord Tissue by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS).- Analysis of Drugs in Oral Fluid using LC-MS/MS.- Determination of Cocaine and Metabolites in Dried Blood Spots by LC-MS/MS.
