Signaling By Toll-Like Receptors

Sommario

Assessing the Response of Cells to TLR Stimulation. TLR Ligands in Experimental Settings: Their Purity and Specificity. Analysis of TLR Expression, Regulation, and Signaling. Intracellular Trafficking of Toll-Like Receptors. The Role of Small RhoGTPases in TLR Signaling. Use of Engineered β-Lactamase Fragment Complementation to Detect the Associations of Toll-Like Receptors and Signaling Adaptors. Use of Toll-Like Receptor Chimeras to Dissect Mechanisms of Receptor Localization and Signaling. Engagement of Toll-Like Receptors Modulates Chemokine Receptor Signaling. Role of Toll-Like Receptor Signaling in Central Nervous System Infections. The Influence of Injury on Toll-Like Receptor Responses. Index.

Riassunto

The discovery of toll-like receptors (TLRs) spurred the field of innate immunity into a renaissance after many years of neglect. Since then, TLR research has grown at an exponential rate. Taking an integrated methodological approach, Signaling by Toll-Like Receptors offers a comprehensive review of important techniques in molecular biology, cell biology, biochemistry, genetics, and immunology and their critical application to the study of toll-like receptor structure, biological function, and the intracellular signaling triggered by these receptors.

Dettagli sul prodotto

• Autori: Gregory W. Konat, Gregory W. (West Virginia University Konat
• Con la collaborazione di: Gregory W. Konat (Editore), Konat Gregory W. (Editore)
• Editore: Taylor & Francis Ltd.
• Lingue: Inglese
• Formato: Tascabile
• Pubblicazione: 31.08.2019
• EAN: 9780367387181
• ISBN: 978-0-367-38718-1
• Pagine: 224
• Categorie: Scienze naturali, medicina, informatica, tecnica > Biologia > Genetica, tecnica genetica; Immunology, SCIENCE / Life Sciences / General, MEDICAL / Immunology, SCIENCE / Life Sciences / Cell Biology, SCIENCE / Research & Methodology, Cellular biology (cytology)