Biomedical Applications of Acridines - Derivatives, Syntheses, Properties and Biological Activities with a Focus on Neurodegenerative Diseases

This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, it presents structures of acridines with nucleic acids and proteins and compares them with the native structures. Furthermore, the book presents modern methods of acridine synthesis, comparing them with the most useful conventional methods. Acridines interact with both nucleic acids and proteins, and due to their direct interactions with various enzymes, they can be suitable for the treatment of neurodegenerative diseases, inflammation, immunological disorders, and protozoal diseases. The characteristic spectral properties of acridines can be employed in labeling proteins, nucleic acids, lipids, and even cells and their compartments. Moreover, they can be applied in photodynamic therapy.

Sommario

Preliminary ToC 1 Introduction.- 2 Nomenclature.- 3. Syntheses.- 4. Interactions of acridines with nucleic acids.- 5. Intercations with proteins.- 6. Applications for treament of neurodegenerative diseases.- 7. Some applications of selective toxicities of acridines.- 8. Acridine on dendrimeric carriers.- 9 Acridines used for staining.- 10 Miscellaneous.- 11 Conclusions and outlook.

Info autore

 

Riassunto

Describes modern and conventional syntheses of acridine scaffolds
Presents structural aspects of interactions with proteins which provide useful tips  for designing enzyme inhibitors involved in the treatment of neurodegenerative diseases
Discusses structural aspects of interactions with nucleic acids, which helps readers to design a specific binder for the targeting of quadruplexes involved in cancer

Dettagli sul prodotto

• Autori: Jaroslav ¿Ebestík, Jan Hlavá¿ek, Ja Hlavácek, Jan Hlavácek, Jan Hlaváček, Jan Je¿ek, Ja Jezek, Jan Jezek, Jan Ježek, Jaroslav Sebestík, Jaroslav Šebestík
• Editore: Springer, Berlin
• Lingue: Inglese
• Formato: Tascabile
• Pubblicazione: 01.01.2018
• EAN: 9783319876801
• ISBN: 978-3-31-987680-1
• Pagine: 237
• Dimensioni: 155 mm x 13 mm x 235 mm
• Peso: 391 g
• Illustrazioni: XIII, 237 p. 79 illus., 25 illus. in color.
• Serie: Progress in Drug Research
• Categorie: Scienze naturali, medicina, informatica, tecnica > Chimica > Chimica fisica; B, ORGANIC CHEMISTRY, Life Sciences, biochemistry, Neurology & clinical neurophysiology, Pharmacology, proteins, Biomedical and Life Sciences, Neurochemistry, Bioorganic Chemistry, Pharmacology/Toxicology, MEDICINAL CHEMISTRY, Nucleic acids, Nucleic Acid Chemistry, Protein-Ligand Interactions, Engineering applications of bio-materials