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This volume focuses on virus-host cell interactions, cellular genes acquired or modulated by viruses, the pathological effects of these interactions, and therapeutic interventions. Several chapters specifically address the role of viruses and genes - such as oncogenes, proto-oncogenes, or tumor suppressor genes - in the etiology of human cancer. Oncogenic signaling by PI3 kinase, mTOR, Akt, or the major cancer drivers MYC and RAF, and the role of tumor suppressors like p53, are discussed in detail. The volume also explores the emerging role of noncoding RNAs such as microRNAs in tumorigenesis and cancer therapeutics, and offers new insights into the role of HIV-host interactions relevant to pathogenesis and treatment. Gathering contributions written by leading scientists in their respective fields, the volume offers a valuable resource for researchers and clinicians alike.
Sommario
Exchange of Genetic Sequences Between Viruses and Host.- Virus-Host Gene Interactions that Define HIV Disease Progression.- Sequencing the Biology of Entry: The Retroviral env Gene.- Infectious Agents in Bovine Red Meat and Milk and Their Potential Role in Cancer and Other Chronic Diseases.- MYC and RAF: Key Effectors in Cellular Signaling and Major Drivers in Human Cancer.- Oncogenic Roles of the PI3K/AKT/mTOR Axis.- MicroRNAs and Cancer.- The Evolution of Tumor Formation in Humans and Mice with Inherited Mutations in the P53 Gene.
Info autore
Eric Hunter, PhD, is a Professor of Pathology and Laboratory Medicine and a Georgia Research Alliance Eminent Scholar, based in Atlanta, GA, USA
Klaus Bister, PhD, is a Professor Emeritus of Biochemistry of University of Innsbruck, Austria, and a Professor Adjunct of The Scripps Research Institute, La Jolla, CA, USA
Riassunto
Includes a foreword by the Nobel laureates J. Michael Bishop and Harold Varmus
Casts new light on the role of viruses and genes in the etiology of human cancer
Discusses the latest developments in HIV vaccine development
