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Drug action in biological systems is a subject of research as they exert their action by the interactions with different bio-macromolecules. Drug-macromolecular interactions involved in different physiological phenomenon, such as drug transport and anaesthesia. These interactions are generally complex in nature and therefore difficult to understand. Physico-chemical and thermodynamic studies provide information regarding the pattern of drug-macromolecular aggregation. Most of the biochemical processes is temperature dependant and occurs in aqueous media. Therefore thermo physical properties of drug-macromolecular systems in aqueous media at different temperatures provide valuable information in medicinal chemistry. Generally drug molecules contains both hydrophilic and hydrophobic groups hence it exhibits a number of specific and non specific interactions in aqueous media. Volumetric, viscometric and acoustic properties are helpful in understanding these interactions
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Dr. Abhijit Sarkar is an engineer in Indian Oil Corporation by profession and a researcher in the University of North Bengal. He has published 16 research articles and 3 books.Dr. Biswajit Sinha is an associate professor in the University of North Bengal. He has published more than 65 research articles in different reputed journals and 4 books.
