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Sommario
Pharmacokinetics, Metabolism, And Percutaneous Penetration Of The Skin. Physiologically-Based Pharmacokinetic Modeling to Predict Tissue Dose and Cholinesterase Inhibition in Workers Exposed to Organophosphorus and Carbamate Pesticides. The Application of Pharmacokinetic Models to Predict Target Dose. Cytochrome P450-Dependent Metabolism of Drugs and Carcinogens in Skin. Percutaneous Absorption. In Vitro Skin Metabolism. Animal Models for Percutaneous Absorption. A Comparative Study of the Kinetics and Bioavailability of Pure and Soil-Absorbed Benzene, Toluene, and M-Xylene After Dermal Exposure. Prediction of Human Percutaneous Absorption with Physicochemical Data. Dermal Absorption of TCDD: Effect of Age. Percutaneous Absorption of Chemicals from Water During Swimming and Bathing. Percutaneous Absorption of Chemicals from Soil. Route Of Exposure And Toxicological Response. General Overview on Toxicological Responses and Routes of Chemical Exposure. Acute Toxicity Testing by the Dermal Route. Subchronic Dermal Exposure Studies with Industrial Chemicals. The Dose Response of Percutaneous Absorption. Reproductive and Developmental Toxicity Studies by Cutaneous Administration. Dermal Carcinogenicity Studies of Petroleum-Derived Materials. Comparison of Results from Carcinogenicity Tests of Two Halogenated Compounds by Oral, Dermal, and Inhalation Routes. The Objectives and Goals of Dermal Carcinogenicity Testing of Petroleum Liquids. Chemical Carcinogenesis in Skin: Causation, Mechanism, and Role of Oncogenes. Dose, Toxicity, And Risk Assessment. Incorporating Biological Information into the Assessment of Cancer Risk to Humans Under Various Exposure Conditions and Issues Related to High Background Tumor Incidence Rates. Phototoxicity of Topical and Systemic Agents. Techniques for Assessing the Health Risks of Dermal Contact with Chemicals in the Environment. Interspecies Extrapolation of Toxicological Data. New Models In Skin Research. Human Skin Xenografts to Athymic Rodents as a System to Study Toxins Delivered to or Through the Skin. The Isolated Perfused Porcine Skin Flap. Epidemiologic Studies Of Route Of Exposure And Health Effects. Perspectives on Assessment of Risk from Dermal Exposure to Polycyclic Aromatic Hydrocarbons. The Paradox of Herbicide 2, 4-D Epidemiology. A Review of Epidemiologic Studies with Regard to Routes of Exposure to Toxicants.
Info autore
Rhoda G. M. Wang, Ph.D., is DABT Regulatory Toxicologist Department of Pesticide Regulation California Environmental Protection Agency, Sacramento, California, USA. James B. Knaak, Ph.D, is Product Stewardship Scientist Occidental Chemical Corporation, Niagara Falls, New York, USA. Howard I. Maibach, M.D., is Professor of Dermatology Department of Dermatology University of California, San Francisco, California, USA.
Riassunto
Health Risk Assessment is a comprehensive reference focusing on dermal absorption, cholinesterase inhibition, adverse reproductive effects, and carcinogenicity. With contributions on topics such as PBPK modeling, cytochrome P-450 metabolism in skin, percutaneous absorption, adverse effects, new skin models, and the role of epidemiology in assessing the hazards of toxicants, Health Risk Assessment is essential for toxicologists, environmental chemists, pharmacologists, risk assessors, and managers working in industrial, pesticide, and pharmaceutical development.
