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The efficient transport of molecules is essential for the normal function of cells and organs and the design of devices for medical applications and biotechnology. Transport Phenomena in Biological Systems provides an introduction to the integrated study of transport processes and their biological applications.
The book consists of four sections, which cover physiological fluid mechanics, mass transport, biochemical interactions and reactions and the effect of mass transfer, and transport in organs and whole organisms. In order to provide students with a firm understanding of biological transport processes, engineering concepts are provided within the context of specific biological problems. Examples and problems elaborate on the concepts in the text or develop new concepts. The introductory chapter presents a brief overview of transport processes at the cell and tissue level and relevant concepts in cell biology and physiology are presented throughout the text. An appendix provides an overview of relevant mathematical concepts used in the text. The problems at the end of each chapter require either analytical solution or numerical solution using MATLAB®.
This book can be used for both introductory and advanced courses. Advanced topics covered include transport in the kidney, oxygen transport, receptor-mediated processes, cell adhesion, transport of drugs in tumors, and whole body pharmacokinetic models. References are provided for further study.
Sommario
Previous Edition TOC
1. Introduction.
A. INTRODUCTION TO PHYSIOLOGICAL FLUID MECHANICS.
2. Conservation and Momentum Balances.
3. Conservation Relations for Fluid Transport, Dimensional Analysis and Scaling.
4. Macroscopic Form of Conservation Relations and Applications of Momentum Transport.
5. Fluid Flow in the Circulation and Tissues.
B. FUNDAMENTALS AND APPLICATIONS OF MASS TRANSPORT.
6. Introduction to Mass Transport.
7. Diffusion with Convection or Electrical Potentials.
8. Transport in Porous Media.
9. Transvascular Transport.
10. Solvent and Solute Transport across the Kidney Glomerulus.
C. THE EFFECT OF MASS TRANSPORT UPON BIOCHEMICAL INTERACTIONS.
11. Mass Transport and Biochemical Interactions.
12. Oxygen Transport from the Lungs to the Tissues.
13. Ligand-Receptor Kinetics on the Cell Surface and Molecular Transport within Cells.
14. Cell Adhesion and Cell Signaling.
15. Transport of Drugs and Macromolecules in Tumors.
16. Transport in Organs and Organisms.
17. Heat Transfer in Biological Systems.
Appendix. Relevant Mathematical Concepts.
Info autore
The authors are faculty members in the Department of Biomedical Engineering at Duke University. The authors are leaders in their respective fields of research and their research has involved various aspects of momentum and mass transport related to biological phenomena and technologies.
Riassunto
For one-semester, advanced undergraduate/graduate courses in Biotransport Engineering.
Presenting engineering fundamentals and biological applications in a unified way, this text provides students with the skills necessary to develop and critically analyze models of biological transport and reaction processes. It covers topics in fluid mechanics, mass transport, and biochemical interactions, with engineering concepts motivated by specific biological problems.
