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Informationen zum Autor T. THOMSON, MS, is Director of Main Street Technologies. He was the founder and Chief Technical Officer of Hydrophilix, Inc., a technology-based firm specializing in the development of advanced medical devices, environmental remediation technologies and consumer products. Mr. Thomson is known for his expertise in the development of products based on hydrophilic polyurethane (HPUR), and his current research includes the application of polyurethane composites to developing scaffolds for cell growth. He wrote 3 books on the subject, holds 7 patents in synthetic chemistry and process control, and has sponsored several seminars on the medical applications of specialty polyurethanes. Klappentext Polyurethane is a material especially suited for immobilizing cells, given its unique properties with applications ranging from environmental remediation to medical devices. While immobilization is well known among environmental engineers, specifically for enzymes, it is less well known among medical researchers. Motivated to fill this need and directed towards biotechnologists working in environmental and medical research, Polyurethane Immobilization of Cells and Biomolecules: Medical and Environmental Applications describes research on the use of polyurethane as an immobilizing agent for cells and active molecules. After an introductory chapter on chemistry, the bulk of the book divides into two sections - medical applications and environmental remediation. They are juxtaposed to create cross-fertilization, meaning a medical researcher can benefit from applications taught in the environmental section and visa-versa. As a valuable resource for applied biotechnologists in different industries, this book offers readers key benefits including: Little or no jargon in a multidisciplinary and lucid writing style The extrapolation of current technology into advanced areas, especially environmental remediation and medical devices A bridge between immobilization research and practical applications Zusammenfassung This book provides a comprehensive review of the chemistry and research illustrating the benefits of polyurethane for immobilizing cells! with dozens of case studies in medical devices and environmental engineering. Inhaltsverzeichnis Preface ix 1 Polyurethane Chemistry 1 Introduction 1 The Chemistry 2 The Isocyanates 3 The Polyol 5 Cross-Linking 5 The Water Reaction 6 Process 8 The One-Shot Process 8 The Prepolymer Process 10 Post Processing 12 Architecture of Polyurethane Foam 14 Grafting to the Polyurethane Foam 16 Biodegradable PUR 19 Mechanism of Biodegradation 23 More Examples 24 Conclusion 25 References 26 2 Laboratory Practice 29 Introduction 29 Prepolymers 30 Preparation of an Elastomer 30 Preparation of Foam 32 Hydrophobic Foams 32 Hydrophilic Foams 34 Custom Prepolymers, Foams, and Scaffolds 40 Examples 43 Structure-Property Relationships 48 The Special Case of Hydrophilic Polyurethane Foams 50 Physical and Chemical Testing 50 Physical Testing 52 Biocompatibility Testing 54 Process Equipment 54 Metering Pump 55 Mixing Head 55 Tank/Material Retaining Container 55 Machine Manufacturers 56 References 56 3 Scaffolds 59 Introduction 59 Bioscaffolds 61 Examples of Biofilter 65 Elimination of Tobacco Odor from a Cigarette-Manufacturing Plant 67 Treatment of VOCs from an Industrial Plant 68 The Liver as Biofilter 68 Scaffolds for Medical Applications (In Vivo and Extracorporeal) 70 The Liver Model 71 The Extracellular Matrix as Scaffold 72 The Physical Scaffold 73 Design of an ...
