Excited States and Free Radicals in Biology and Medicine - Contributions from Flash Photolysis and Pulse Radiolysis

This book is a synthesis of the key developments in research on excited states and free radicals bringing together theory and research results in biomedical systems. The authors are noted in this field and the text will appeal to those engaged in research on anti-cancer therapies and also on light- and radiation-induced dermatological problems.

Riassunto

Excited states and free radicals are involved in the normal physiology of living systems; in pathological processes including lipid peoxidation, inflammation, Parkinson's disease, cancer, and ageing; in the mechanism of action of drugs, such as quinone antitumour agents, and in the photochemotherapies such as the PUVA therapy of skin diseases and PDT of cancer. The chief aim of this text is to introduce the reader to this rapidly expanding field, which lies at the borderlines of physics, chemistry, biology, pharmacology, and medicine, and, in particular, to explore how time-resolved spectroscopic methods have found solutions at the molecular level to biological and medical problems.

In the first three chapters, the nature of excited states and free radicals, and the fast kinetic and spectroscopic techniques for their study are described. Amongst the biological areas described in the subsequent chapters are: activated oxygen species; DNA; proteins; carotenoids and photosynthetic reaction centres; photodermatology and melanogenesis; and aspects of cancer related to radio-, chemo-, and photodynamic therapy.

Testo aggiuntivo

contains a considerable amount of useful information ... It is well written ... very pleasant and interesting to read ... Students, researchers, and also physicians ... will find competently written introductions to the field, a large amount of interesting information, both on basic research and applications, and a detailed bibliography.

Dettagli sul prodotto

• Autori: R. V. Bensasson, R. V. (Directeur de Recherche au CNRS Bensasson, Bensasson R. V., etc., E. J. Land, E. J. (Senior Scientist Land, E.J. Land, T. G. Truscott, T. G. (Professor of Physical Chemistry Truscott, T.G. (Professor of Physical Chemistry Truscott
• Editore: Oxford Academic
• Lingue: Inglese
• Formato: Copertina rigida
• Pubblicazione: 16.09.1993
• EAN: 9780198555605
• ISBN: 978-0-19-855560-5
• Dimensioni: 162 mm x 235 mm x 30 mm
• Peso: 800 g
• Illustrazioni: line figures, tables
• Serie: Oxford Science Publications
• Categorie: Scienze naturali, medicina, informatica, tecnica > Biologia > Biochimica, biofisica; Scienze umane, arte, musica > Scienze linguistiche e letterarie > Letteratura / linguistica inglese; Medical research, SCIENCE / Life Sciences / Biochemistry, SCIENCE / Life Sciences / Cell Biology, MEDICAL / Research, biochemistry, Oncology, Cellular biology (cytology)