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Sommario
1. Lessons from H 3, A Model Autosomal Mouse Minor Histocompatibility Locus 2. Sizing Up the Set of H Genes in Mice 3. Som e Personal Reflections on the History of Minor Histocompatibility Research 4. Identifying T Cell-Defined Histocompatibility Antigens by Expression Cloning 5. Mitochondrially-Encoded Minor Histocompatibility Antigens 6. The Male-Specific Minor Histocompatibility Antigen, HY 7. Mechanism s and Implications of Immunodominance 8. Human M in or Histocompatability Antigens: Towards Clinical Benefits. 9. Mapping Human Minor Histocompatability Genes 10. Applicability of Matching for Minor Histocompatability Antigens in Human Bone Marrow Transplantation 11. Genetic Linkage Analysis to Identify Minor Histocompatability Loci Contributing to Graft Versus Host Disease 12. Mouse Models for Graft-Versus-Host Disease 13. The Diversity and Characteristics of T -Cell Receptors Specific for Single N on -H 2 Histocompatability Antigens 14. Infectious Tolerance with CD4 Monoclonal Antibodies: A Role for Minors in Linked Suppression 15. Skin-Specific Minor Histocompatibility Antigens: A Critical Appraisal 16. Antigens Encountered During Organ Transplantation 17. Human Tumor Antigens Recognizes by Cytolytic T Lymphocytes: Towards Vaccination
Info autore
Derry Roopenian, Ph.D., The Jackson Laboratory, Bar Harbor, Maine, U.S.A. Elizabeth Simpson, M.A. Vet. M.B. F.Med. Sci. MRC Clinical Sciences Centre ICSM, Hammersmith Hospital, London, U.K.
Riassunto
With the widespread application of solid tissue and bone marrow transplantation as a treatment for an array of life threatening disorders, there is a pressing need for clinicians and experimentalists to understand the basis of immunological rejection of tissue transplants
