Fr. 237.00

The Smoothened Receptor in Cancer and Regenerative Medicine

Inglese · Tascabile

Spedizione di solito entro 6 a 7 settimane

Descrizione

Ulteriori informazioni

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Sommario

Canonical and non canonical Hedgehog signaling pathways, coupling to G-proteins.- Pharmacochemistry of the Smoothened receptor: Agonists, antagonists, allosteric modulators.- Receptor modifications in Hedgehog regulation.- Smoothened, stem cell maintenance and brain diseases.- Medulloblastoma, pediatric brain tumors and Smoothened blockade.- Role of Smoothened and Hedgehog signaling in angiogenesis, neovascularization.- Implications in stem cell maintenance.- Comparison of the crystal structure of Smoothened to known GPCRs structure.

Dettagli sul prodotto

Con la collaborazione di Martia Ruat (Editore), Martial Ruat (Editore)
Editore Springer, Berlin
 
Lingue Inglese
Formato Tascabile
Pubblicazione 01.01.2016
 
EAN 9783319354026
ISBN 978-3-31-935402-6
Pagine 210
Dimensioni 155 mm x 12 mm x 235 mm
Peso 341 g
Illustrazioni VII, 210 p.
Serie Topics in Medicinal Chemistry
Topics in Medicinal Chemistry
Categorie Scienze naturali, medicina, informatica, tecnica > Chimica > Chimica fisica

Biochemie, Onkologie, C, biochemistry, Oncology, Chemistry and Materials Science, proteins, Cancer Research, MEDICINAL CHEMISTRY, Receptors, Cancer Biology

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