RNA and DNA Diagnostics

The aim of molecular diagnostics is preferentially to detect a developing disease before any symptoms appear. There has been a significant increase, fueled by technologies from the human genome project, in the availability of nucleic acid sequence information for all living organisms including bacteria and viruses. When combined with a different type of instrumentation applied, the resulting diagnostics is specific and sensitive. Nucleic acid-based medical diagnosis detects specific DNAs or RNAs from the infecting organism or virus and a specific gene or the expression of a gene associated with a disease. Nucleic acid approaches also stimulate a basic science by opening lines of inquiry that will lead to greater understanding of the molecules at the center of life. One can follow Richard Feynman's famous statement "What I cannot create, I do not understand."

Sommario

Electrochemical Biosensors for miRNA Detection.- Electrochemical Detection of RNA.- DNA and PNA probes for DNA Detection in Electroanalytical Systems.- DNA for Non-Nucleic Acid Sensing.- Aptamers in Oncotherapy.- Genotyping of Single Nucleotide Polymorphism.- Environmentally Responsive and Bright Fluorescent Probes Possessing Dansyl-modified Oligonucleotides under Hybridization of DNA and RNA.- Fluorescent Nucleic Acid Analogues in Research and Clinical Diagnostics.- Emergent Properties and Functions of Nanoconfined Nucleic Acid Architectures.- RNA and DNA Diagnostics on Microspheres: Current and Emerging Methods.- DNA and RNA Electronic Properties for Molecular Modifications and Environmental State Diagnostics.- Mechanochemical Sensing.- Microarrays as Research Tools and Diagnostic Devices.- Quadruplex Priming Amplification (QPA) for Nucleic Acid Diagnostics.- Single-molecule strategies for DNA and RNA diagnostics.- Detection and Assessment of microRNA Expression in Human Disease.

Dettagli sul prodotto

• Con la collaborazione di: Jan Barciszewski (Editore), Volker A. Erdmann (Editore), Stefa Jurga (Editore), Stefan Jurga (Editore)
• Editore: Springer, Berlin
• Lingue: Inglese
• Formato: Tascabile
• Pubblicazione: 01.01.2016
• EAN: 9783319361994
• ISBN: 978-3-31-936199-4
• Pagine: 349
• Dimensioni: 155 mm x 19 mm x 235 mm
• Peso: 546 g
• Illustrazioni: X, 349 p. 124 illus., 78 illus. in color.
• Serie: RNA Technologies; RNA Technologies
• Categorie: Scienze naturali, medicina, informatica, tecnica > Medicina > Branche cliniche; B, Medical research, biochemistry, molecular biology, biotechnology, Human Genetics, Biomedical and Life Sciences, Medical Genetics, Biomedical Research, Molecular Medicine, Nucleic acids, Nucleic Acid Chemistry, Nucleic Acid, Engineering applications of bio-materials