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In 1994 the European Society of Urogenital Radiology (ESUR) set up a committee to consider the safety of contrast media used for diagnostic imaging. Subsequently the committee questioned members, reviewed the literature, proposed guidelines and discussed these proposals with participants at the annual symposia of the society. The end result of this work was the successful first edition of this book, published in 2006. This second edition not only updates the previous edition, but also contains some completely new chapters, for example on gadolinium-based contrast agents, meta-analyses in contrast media research and various regulatory issues.
Comprehensive consideration is given to the many different safety issues relating to iodinated, MR, ultrasound and barium contrast media. The text includes chapters on both acute and delayed non-renal adverse reactions and on renal adverse reactions. All those questions frequently raised in radiological practice are addressed, and the well-known ESUR guidelines on contrast media are included. This book, presented in a handy, easy to use format, provides an invaluable, unique and unparalleled source of information on the safety issues relating to contrast media.
Sommario
Section I General Issues
1 Classification and Terminology
Peter Aspelin, Marie-France Bellin, Jarl Å. Jakobsen, and Judith A. W. Webb
2 Requests for Imaging Using Contrast Agents What Information Must be Provided
Samed K. Morcos and Marie-France Bellin
3 Off-Label Use of Medicines Legal Aspects
June M. Raine
4 Pharmacovigilance When to Report Adverse Reactions
Doris I. Stenver
5 What is Required in Order to Get the Authorities to Approve an New Contrast Agent
Doris I. Stenver
6 A Critical Review of Meta-Analysis of Adverse Events After Contrast Agents
Giuseppe Biondi Zoccai and Maria Lotrionte
Section II Iodinated and Gadolinium Contrast Media
A. General Adverse Reactions
7 Prevention of Acute Reactions
Judith A.W. Webb
8 Management of Acute Adverse Reactions
Henrik S. Thomsen
B. Renal Adverse Effects
9 Contrast Medium Induced Nephropathy
Henrik S. Thomsen
10 Dialysis and Contrast Media
Sameh K. Morcos
11 Non-Insulin Dependent Diabetes and Contrast Media
Judith A.W. Webb
C. Other Adverse Effects
12 Pregnancy and Lactation
Judith A. W. Webb
13 Phaechromocytoma
Judith A.W. Webb
14 Interactions with Other Drugs and Clinical Tests
Sameh K. Morcos
15 Extravasation Injury
Jarl Å. Jakobsen
Section III Iodinated Contrast Media
16 Late Adverse Reactions
Fulvio Stacul
17 Effects on the Blood and Endothelium
Peter Aspelin, Fulvio Stacul, and Sameh K. Morcos
18 Effect on Thyroid Function
Aart van der Molen
19 Pulmonary Effects
Sameh K. Morcos
Section IV MR Contrast Media
A. Non-Tissue Specific Extracellular MR Contrast Media
20 Chelates and Stability
Sameh K. Morcos
21 Diagnostic Efficacy
Aart van der Molen
22 Radiography with Gadolinium Contrast Agents
Henrik S. Thomsen
B. Gadolinium-Based Contrast Agents23 Acute Adverse Reactions
Gertraud Heinz-Peer
24 Delayed Reactions: Nephrogenic Systemic Fibrosis (NSF)
Henrik S. Thomsen
C. Organ-Specific MR Contrast Agents
25 Gadolinium Based Contrast Agents
Marie-France Bellin
26 Non-Gadolinium Based Contrast Agents
Marie-France Bellin
Section V - Ultrasonographic Contrast Media
27 Safety of Ultrasonographic Agents
Raymond Oyen
Section VI Barium Preparations
28 Barium Preparations: Safety Issues
Sameh K. Morcos
Appendix
29 ESUR Guidelines on Contrast Media
Contrast Media Safety Committee
30 Official Publications from the Contrast Media Safety Committee of the
European Society of Urogenital Radiology
Contrast Media Safety Committee
Subject Index
List of Contributors
