Mechanisms of Atrial Arrhythmias - Insights from the Development of a Biophysically Detailed Model of the Human Atria

This thesis describes the development of biophysically detailed computer models of the human atria and torso to study the underlying mechanisms of cardiac diseases, some of the most common causes of morbidity and mortality. This is a cross-disciplinary project, involving fundamentals of cardiac electrophysiology, physics of excitable media, applied mathematics and high performance scientific computing and visualisation. The author uses computer models to provide insights into the underlying mechanisms of the genesis of atrial fibrillation and develops novel techniques for the monitoring of atrial tachycardia.

Sommario

Introduction.- Background.- Development of a new model for simulating the electrical action potentials of human atrial myocytes.- Development of a family of regional cell models.- Autonomic regulation and pathophysiological remodelling.- 3D Anatomical Modelling of the Atria.- Pacemaking and autonomic regulation in the 3D sinoatrial node and atria.- Atrial Fibrillation.- Discussion.

Riassunto

This thesis describes the development of biophysically detailed computer models of the human atria and torso to study the underlying mechanisms of cardiac diseases, some of the most common causes of morbidity and mortality. This is a cross-disciplinary project, involving fundamentals of cardiac electrophysiology, physics of excitable media, applied mathematics and high performance scientific computing and visualisation. The author uses computer models to provide insights into the underlying mechanisms of the genesis of atrial fibrillation and develops novel techniques for the monitoring of atrial tachycardia.

Dettagli sul prodotto

• Autori: Michael A Colman, Michael A. Colman
• Editore: Springer, Berlin
• Lingue: Inglese
• Formato: Tascabile
• Pubblicazione: 01.01.2016
• EAN: 9783319348773
• ISBN: 978-3-31-934877-3
• Pagine: 256
• Dimensioni: 155 mm x 15 mm x 235 mm
• Peso: 429 g
• Illustrazioni: XXII, 256 p. 137 illus., 42 illus. in color.
• Serie: Springer Theses; Springer Theses
• Categorie: Scienze naturali, medicina, informatica, tecnica > Biologia > Biochimica, biofisica; B, Cardiology, bioinformatics, Physics, Biology, life sciences, Theoretical, Mathematical and Computational Physics, Physics and Astronomy, Medical physics, Biophysics, Mathematical physics, Information technology: general issues, Biological physics, Biological and Medical Physics, Biophysics, Numerical and Computational Physics, Simulation, Mathematical modelling, Cardiovascular medicine, Computational and Systems Biology, Mathematical Applications in the Physical Sciences, Computational biology, Computer Appl. in Life Sciences