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To clarify the pathophysiological background of attention deficit/hyperactivity disorder (AD/HD) and its comorbidity with oppositional defiant/conduct disorder (ODD/CD) neuropsychological and electrophysiological correlates were investigated. AD/HD cannot be fully explained by an inhibition-specific deficit. Impairments of attentional orienting, response preparation, and response execution processes are implicated as well. Motor response control was particularly impaired in AD/HD+ODD/CD, while AD/HD-only was more impaired in attentional orienting and motor preparation. A dysregulation of central noradrenergic networks is likely. AD/HD+ODD/CD rather represents a separate pathological entity, which differs from both AD/HD-only and ODD/CD-only, than an additive co-occurrence of AD/HD and ODD/CD.
Sommario
Contents: Summary of the current knowledge about attention deficit/hyperactivity disorder, oppositional defiant/conduct disorder and their comorbidity - Introduction to the methodology of the event-related potentials - Investigation of neuropsychological and electrophysological correlates - Theoretical discussion of these new emprical findings in the context of current models of AD/HD.
Info autore
The Author: Tobias Banaschewski, born 1961; 1979-1993 Psychology school & Medical school, University of Marburg; 2002 Board qualification as child and adolescent psychiatrist; 2003 German research award for biological child and adolescent psychiatry for special scientific performance in clinical research, particularly for research into attention deficit hyperactivity disorder (Kramer-Pollnow-Preis); 2004 Habilitation for child and adolescent psychiatry/psychotherapy, University of Göttingen; since 2002 Executive assistant medical director, Child and Adolescent Psychiatry, University of Göttingen.
