A Novel Enantioselective Synthesis of Spiro-Oxindoles - Analogs of Horsifiline and Spirotryprostatin

Spiro-Pyrrolidine-Oxindole is a recurring structural element that has been identified in numerous alkaloids and pharmacologically active compounds. These spiro-fused ring systems embody stereochemical and structural complexities that continue to challenge the synthetic chemist. This book describes a novel enantioselective synthesis of the spiro-pyrrolidine-oxindole ring system in a highly convergent manner.The key steps for the synthesis involve 1,3-dipolar cycloaddition reaction to form the pyrrolidine ring system and radical reaction for the formation of quarternary center. The present synthesis is efficient and would allow preparation of a library of compounds for biological screening.

Info autore

Sesha Sridevi Alluri- A Doctoral student, working with Prof. A. K. Ganguly at stevens Institute of Technology, NJ, USA. She is a co-inventor on two patents and a recipient of several awards and fellowships.

Dettagli sul prodotto

• Autori: Sesha Sridev Alluri, Sesha Sridevi Alluri, Mi Bertucci, Michael Bertucci, Chih-Hun Wang, Chih-Hung Wang
• Editore: LAP Lambert Academic Publishing
• Lingue: Inglese, Tedesco
• Formato: Tascabile
• Pubblicazione: 01.01.2010
• EAN: 9783838355085
• ISBN: 978-3-8383-5508-5
• Pagine: 76
• Categoria: Scienze naturali, medicina, informatica, tecnica > Chimica > Chimica organica