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This book covers the recent advances in the development of bioelectronics systems and their potential application in future biomedical applications starting from system design to signal processing for physiological monitoring, to in situ biosensing.
Advanced Bioelectronics Materialshas contributions from distinguished international scholars whose backgrounds mirror the multidisciplinary readership ranging from the biomedical sciences, biosensors and engineering communities with diverse backgrounds, interests and proficiency in academia and industry. The readers will benefit from the widespread coverage of the current literature, state-of-the-art overview of all facets of advanced bioelectronics materials ranging from real time monitoring, in situ diagnostics, in vivo imaging, image-guided therapeutics, biosensors, and translational biomedical devices and personalized monitoring.
Sommario
Preface xv
Part 1: Recent Advances in Bioelectronics 1
1 Micro- and Nanoelectrodes in Protein-Based Electrochemical Biosensors for Nanomedicine and Other Applications 3
Niina J. Ronkainen
1.1 Introduction 4
1.2 Microelectrodes 7
1.2.1 Electrochemistry and Advantages of Microelectrodes 7
1.2.2 Applications, Cleaning, and Performance of Microelectrodes 16
1.3 Nanoelectrodes 18
1.3.1 Electrochemistry and Advantages of Nanoelectrodes 21
1.3.2 Applications and Performance of Nanoelectrodes 23
1.4 Integration of the Electronic Transducer, Electrode, and Biological Recognition Components (such as Enzymes) in Nanoscale-Sized Biosensors and Their Clinical Applications 26
1.5 Conclusion 27
Acknowledgment 28
References 28
2 Radio-Frequency Biosensors for Label-Free Detection of Biomolecular Binding Systems 35
Hee-Jo Lee1, Sang-Gyu Kim, and Jong-Gwan Yook
2.1 Overview 35
2.2 Introduction 36
2.3 Carbon Nanotube-Based RF Biosensor 37
2.3.1 Carbon Nanotube 37
2.3.2 Fabrications of Interdigital Capacitors with Carbon Nanotube 38
2.3.3 Functionalization of Carbon Nanotube 39
2.3.4 Measurement and Results 40
2.4 Resonator-Based RF Biosensor 40
2.4.1 Resonator 40
2.4.2 Sample Preparation and Measurement 42
2.4.3 Functionalization of Resonator 42
2.5 Active System-Based RF Biosensor 45
2.5.1 Principle and Configuration of System 45
2.5.2 Fabrication of RF Active System with Resonator 46
2.5.2.1 Functionalization of Resonator 46
2.5.3 Measurement and Result 47
2.6 Conclusions 49
Abbreviations 51
References 52
3 Affinity Biosensing: Recent Advances in Surface Plasmon Resonance for Molecular Diagnostics 55
S. Scarano, S. Mariani, and M. Minunni
3.1 Introduction 56
3.2 Artists of the Biorecognition: New Natural and Synthetic Receptors as Sensing Elements 58
3.2.1 Antibodies and Their Mimetics 58
3.2.2 Nucleic Acids and Analogues 62
3.2.3 Living Cells 63
3.3 Recent Trends in Bioreceptors Immobilization 65
3.4 Trends for Improvements of Analytical Performances in Molecular Diagnostics 69
3.4.1 Coupling Nanotechnology to Biosensing 70
3.4.2 Microfluidics and Microsystems 76
3.4.3 Hyphenation 78
3.5 Conclusions 78
References 80
4 Electropolymerized Materials for Biosensors 89
Gennady Evtugyn, Anna Porfi reva and Tibor Hianik
4.1 Introduction 89
4.2 Electropolymerized Materials Used in Biosensor Assembly 93
4.2.1 General Characteristic of Electropolymerization Techniques 93
4.2.2 Instrumentation Tools for Monitoring of the Redox-Active Polymers in the Biosensor Assembly 97
4.2.3 Redox-Active Polymers Applied in Biosensor Assembly 99
4.3 Enzyme Sensors 107
4.3.1 PANI-Based Enzyme Sensors 107
4.3.2 PPY and Polythiophene-Based Enzyme Sensors 117
4.3.3 Enzyme Sensors Based on Other Redox-Active Polymers Obtained by Electropolymerization 127
4.3.4 Enzyme Sensors Based on Other Polymers Bearing Redox Groups 135
4.4 Immunosensors Based on Redox-Active Polymers 137
4.5 DNA Sensors Based on Redox-Active Polymers 149
4.5.1 PANI-based DNA Sensors and Aptasensors 149
4.5.2 PPY-Based DNA Sensors 153
4.5.3 Thiophene Derivatives in the DNA Sensors 157
4.5.4 DNA Sensors Based on Polyphenazines and Other Redox-Active
Info autore
Ashutosh Tiwari is Chairman and Managing Director of Tekidag AB; Group Leader, Advanced Materials and Biodevices at the world premier Biosensors and Bioelectronics Centre at IFM, Linköping University; Editor-in-Chief,
Advanced Materials Letters and
Advanced Materials Reviews; Secretary General, International Association of Advanced Materials; a materials chemist and docent in the Applied Physics with the specialization of Biosensors and Bioelectronics from Linköping University, Sweden. He has more than 400 publications in the field of materials science and nanotechnology with h-index of 30 and has edited/authored over 25 books on advanced materials and technology. He is a founding member of the Advanced Materials World Congress and the Indian Materials Congress.
Hirak K Patra completed his PhD in 2007 on "
Synthetic Nanoforms as Designer and Explorer for Cellular Events" at the University of Calcutta, well known for its fundamental education system with three Nobel Laureates in Asia. He moved to the Applied Physics Division of Linköping University with the prestigious Integrative Regenerative Medicine fellowship at Sweden to work with the Prof. Anthony Turner at his Biosensors and Bioelectronics Center. He has published 17 articles in top journals, 4 patents, and has been honored with several "Young Scientist" awards globally.
Riassunto
This book covers the recent advances in the development of bioelectronics systems and their potential application in future biomedical applications starting from system design to signal processing for physiological monitoring, to in situ biosensing.
Advanced Bioelectronics Materialshas contributions from distinguished international scholars whose backgrounds mirror the multidisciplinary readership ranging from the biomedical sciences, biosensors and engineering communities with diverse backgrounds, interests and proficiency in academia and industry. The readers will benefit from the widespread coverage of the current literature, state-of-the-art overview of all facets of advanced bioelectronics materials ranging from real time monitoring, in situ diagnostics, in vivo imaging, image-guided therapeutics, biosensors, and translational biomedical devices and personalized monitoring.
