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The book presents current affairs of Sporotrichosis as emergent disease with emphasis on the potential factors associated with genetic polymorphisms in Sporothrix complex. Constitutive and inducible factors play an essential role in the response of the fungal cell to the environment as determinant in the immunopathogenicity, highlighting clinical forms of Sporotrichosis and host immunocompetence. Also, a current issue interest in zoonotic transmission showing that a cat is the animal species most affected by Sporothrix species and their importance in the involvement in the human transmission. Readers can associate parameters of experimental immune response to disease development as well as the diagnostic, prophylaxis, and therapies that can be applied in the near future.
Sommario
1.Sporotrichosis an emergent disease.- 2.Sporothrix schenckii complex: Genetic polymorphyms.- 3.Inmunomodulators components of the Sporothrix schenckii complex.- 4.Environmental conditions and fungal immunopathogenicity: A dual effect.- 5.Clinical forms of Sporotrichosis and host immunocompetence.- 6.Sporotrichosis in animals: Zoonotic transmition.- 7.Models of experimental Sporotrichosis and immune response against Sporothrix schenckii.- 8.Immunodiagnostic: Current status and perspectives.- 9.Antifungal vaccines: Approaching anti-sporothrix immunoprophilaxis.- 10.Therapeutic tools: Old strategies and new tendencies.
Info autore
Dr. Carlos graduated in Pharmacy and Biochemistry from UNESP, Brazil. Also got her masters in Pharmacy, Clinical Analysis in Pharmaceutical Sciences from the same University in 1985, and her PhD in Immunology from the University of Sao Paulo – USP in 1989. She is currently working as Full Professor in Immunology from the Pharmaceutical Sciences Dept. at UNESP. She has experience in Pharmacy with emphasis in Immunology, acting in the immune response in Sporotrichosis, an emerging fungal infection with increased number of cases zoonotic and human. Her research has focused on to characterize the involvement of molecular mediators such as nitric oxide and the related enzyme, inducible nitric oxide synthase, and cytokines among others.
Riassunto
The book presents current affairs of Sporotrichosis as emergent disease with emphasis on the potential factors associated with genetic polymorphisms in Sporothrix complex. Constitutive and inducible factors play an essential role in the response of the fungal cell to the environment as determinant in the immunopathogenicity, highlighting clinical forms of Sporotrichosis and host immunocompetence. Also, a current issue interest in zoonotic transmission showing that a cat is the animal species most affected by Sporothrix species and their importance in the involvement in the human transmission. Readers can associate parameters of experimental immune response to disease development as well as the diagnostic, prophylaxis, and therapies that can be applied in the near future.
