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This supplement presents the papers submitted at the 27th meeting of the European Society of Toxicology, which was organised by the British Toxicology Society and held in Harrogate, England. As evident from the title of this book, the overall theme of the meeting was an exploration of some of the mechanisms of toxicity, as well as some models used in the investigation of toxic action. The topics dealt with can be grouped under four headings. The first of these, on the mechanisms involved in cell injury, was a joint symposium of the European Society of Toxicology and the Society of Toxicology of the United States of America. In the second group, mechanisms in carcinogen risk assessment were discussed. Mechanisms and models of teratogenesis was the subject of the third group of invited papers. Finally, a workshop on safety evaluation of biotechnological products dealt with present and future problems which this new area of technology poses for toxicologists. Short communications on recent studies and developments in toxicological techniques which were presented at the meeting are also included in this volume.
Sommario
Mechanisms of Cell Injury.- Mechanisms in Cancer Risk Assessment.- Mechanisms and Models of Teratogenesis.- Safety Evaluation of Biotechnology Products.- Recent Studies and Technique Developments in Toxicology.- Abstracts.- Depletion of Hepatic Glutathione in The Guinea-Pig after Administration of (±)-Buthionine Sulphoxime.- The Acute Effect of Buthione Sulphoxime on the Glutathione Content of Mouse Liver.- How Much Can Arsenate Compete with Phosphate in Living Cells?.- Effect of Exposure Time on the In Vitro Teratogenicity of Retinoic Acid.- The Effect of Organic Solvents on Human Erythrocyte Membrane Adenosine Triphosphatase Activities In Vitro.- The Perchlorate Discharge Test for Examining Thyroid Function in Rats.- Pathological Changes in the Liver BALB/c Mice Induced by N-Methylformamide.- The Effect of 1,3-Dinitrobenzene and Mono-(2-Ethylhexyl) phthalate on Lactate and Pyruvate Production by Rat Sertoli Cell Cultures.- Toxicity of the Potential Antineoplastic Agent Ambazone.- Reproduction Study of Rifaximin (L/105) In Rats.- An Aid to the Maintenance of Disease-Free Animals.- Author Index.
