Protein Condensation - Kinetic Pathways to Crystallization and Disease

Explains for researchers the rapidly evolving field of protein condensation and the relation to disease.

Sommario

Preface; 1. Introduction; 2. Globular protein structure; 3. Experimental methods; 4. Thermodynamics and statistical mechanics; 5. Protein-protein interactions; 6. Theoretical studies of equilibrium; 7. Nucleation theory; 8. Experimental studies of nucleation; 9. Lysozyme; 10. Some other globular proteins; 11. Membrane proteins; 12. Crystallins and cataracts; 13. Sickle hemoglobin and sickle cell anemia; 14, Alzheimer's disease; Index.

Info autore

J. D. Gunton is Joseph A. Waldschmitt Professor of Physics at Lehigh University in Pennsylvania. He is the author of approximately 200 articles in refereed journals on equilibrium and nonequilibrium phase transitions. He is a Rhodes Scholar and a Danforth Fellow, and a Fellow of the American Physical Society.A. Shiryayev is a doctoral candidate at Lehigh University. He has already published several refereed articles that deal with the condensation of globular proteins.D. L. Pagan received is PhD degree from Lehigh University in 2005. He has authored several refereed articles on the condensation of globular proteins.

Riassunto

For an interdisciplinary graduate and academic audience, this book describes protein crystallization from solution. The first part explains the production of high quality protein crystals, which is necessary to understand protein structure and function. The second part concerns the aggregation of proteins in undesirable ways, which can cause disease.

Dettagli sul prodotto

• Autori: James D. Gunton, James D. (Lehigh University Gunton, James D. Shiryayev Gunton, Gunton James D., Daniel L. Pagan, Pagan Daniel L., Andrey Shiryayev, Shiryayev Andrey
• Editore: Cambridge University Press ELT
• Lingue: Inglese
• Formato: Tascabile
• Pubblicazione: 17.07.2014
• EAN: 9781107424272
• ISBN: 978-1-107-42427-2
• Pagine: 394
• Categorie: Scienze naturali, medicina, informatica, tecnica > Biologia > Biochimica, biofisica; SCIENCE / Life Sciences / Biochemistry, SCIENCE / Life Sciences / Molecular Biology, SCIENCE / Life Sciences / Cell Biology, SCIENCE / Life Sciences / Biophysics, biochemistry, molecular biology, proteins, Cellular biology (cytology), Biophysics