Vitamin D

Vitamin D, a steroid hormone, has mainly been known for its effects on bone and osteoporosis. The current therapeutic practices expand into such markets as cancer research, pediatrics, nephrology, dermatology, immunology, and genetics. This 3e includes over 100 chapters covering everything from chemistry and metabolism to mechanisms of action, diagnosis and management, new analogs, and emerging therapies. This complete reference works is a must-have resource for anyone working in endocrinology, osteology, bone biology, or cancer research.

Most comprehensive, up-to-date two-volume set on Vitamin D
Initial chapters cover the chemistry and metabolism of vitamin D, role in mineralization, other target organs, and general physiological effects
Second volume is more clinically oriented addressing deficiency problems (including diagnosis, interactions in the endocrine system, and involvement in malignancies)
Further sections on emerging uses for treatments of auto-immune diseases and diabetes
New chapters on squamous cell cancer, brain cancer, thyroid cancer and many more
Over 600 illustrations and figures available on CD

Sommario

Section I: Chemistry, Metabolism, Circulation

1 Historical Overview of Vitamin D

Hector F. Deluca

2 Photobiology of Vitamin D

Michael F. Holick

3 The Activating Enzymes of Vitamin D Metabolism (25- and 1a-Hydroxylases)

Glenville Jones and David E. Prosser

4 CYP24A1: Structure, Function, and Physiological Role

Rene St. Arnaud

5 The Vitamin D Binding Protein: DBP

Roger Bouillon

6 Industrial Aspects of Vitamin D

Arnold L. Hirsch

Section II: Mechanisms of Action

7 VDR

J. Wesley Pike

8 Nuclear Vitamin D Receptor: Natural Ligands, Molecular Structure-Function, and Transcriptional Control of Vital Genes

Mark R. Haussler, Carol A. Haussler, Jui-Cheng Hsieh, Peter W. Jurutka, and G. Kerr Whitfield

9 Structural Basis for Ligand Activity in VDR

Dino Moras and Natacha Rochel

10 Coregulators of VDR-mediated Gene Expression

Paul McDonald and Diane R. Dowd

11 Target Genes of Vitamin D: Spatio-temporal Interaction of Chromatin, VDR and Response Elements

Carsten Carlberg

12 Epigenetic Modifications in Vitamin D Receptor Mediated Transrepression

Shigeaki Kato, Alexander Kouzmenko, Fumiaki Ohtake, and Ryoji Fujiki

13 Vitamin D and Wnt/ß-Catenin Signaling

Albert Munoz, José Manuel González-Sancho, and María Jesús Larriba

14 Vitamin D Response Element Binding Protein

John S. Adams, Thomas S. Lisse, Hong Chen, Mark S. Nanes, and Martin Hewison

15 Vitamin D Sterol/VDR Conformational Dynamics and Nongenomic Actions

Anthony W. Norman and Mathew T. Mizwicki

Section III: Mineral and Bone Homeostasis

16 Development of the Skeleton

Jane B. Lian, Gary S. Stein, Martin Montecino, Janet L. Stein, Andre J. van Wijnen

17 Vitamin D Regulation of Osteoblast Function

Renny Franchesci and Yan Li

18 Osteoclasts

F. Patrick Ross

19 Molecular Mechanisms for Regulation of Intestinal Calcium and Phosphate Absorption by Vitamin D

James Fleet and Ryan D. Schoch

20 The Calbindins: Calbindin-D28K and Calbindin-D9K and the Epithelial Calcium Channels TRPV5 and TRPV6

Sylvia Christakos, Leila Mady, and Puneet Dhawan

21 Mineralization

Adele Boskey and Eve Donnelly

22 VITAMIN D REGULATION OF TYPE I COLLAGEN EXPRESSION IN BONE

Barbara Kream and Alexander Lichtler

23 Target Genes: Bone Proteins

Howard Morris, Paul H. Anderson, Gerald J. Atkins, and David M. Findlay

24 Vitamin D and the Calcium-Sensing Receptor

Edward M. Brown

25 Effects of 1,25-Dihydroxyvitamin D3 on Voltage-Sensitive Calcium Channels in Osteoblast Differentiation and Morphology

Mary Farach-Carson and William R. Thompson

Section IV: Targets (David/John/Wes)

26 Vitamin D and the Kidney

Rajiv Kumar and Peter Tebben

27 Vitamin D and the Parathyroids

Justin Silver and Tally Neveh-Many

28 Cartilage

Barbara D. Boyan, Maryam Doroudi and Zvi Schwartz

29 Vitamin D and Oral Heath

Ariane Berdal, Muriel Molla, Vianney Descroix

30 The Role of Vitamin D and its Receptor in Skin and Hair Follicle Biology

Marie B. Demay

31 Vitamin D and the Cardiovascular System

David Gardner, Songcang Chen, Denis Glenn, and Wei Ni

32 Vitamin D: A Neurosteroid Affecting Brain Development and Function; Implications for Neurological and Psychiatric Disorders

John McGrath, Darryl Eyles, and Thomas Burne

33 Contributions of Genetically Modified Mouse Models to Understanding the Physiology and Pathophysiology of the 25-hydroxyvitamin D-1-alpha Hydroxylase Enzyme [1a(OH)ase] and the Vitamin D Receptor (VDR)

David Goltzman, Geoffrey N. Hendy, and Richard Kremer

Section V: Human Physiology

34 Vitamin D: Role in the Calcium and Phosphorus Economies

Robert P. Heaney

35 Fetus, Neonate and Infant

Chris Kovacs

36 Vitamin D Deficiency and Calcium Absorption During Childhood

Steven A. Abrams

37 Adolescence and Acquisition of Peak Bone Mass

Connie Weaver, Rick Lewis, and Emma Liang

38 Vitamin D Metabolism in Pregnancy and La

Relazione

"In this brief review, it is impossible to cover all the nuances of vitamin D addressed in this book. Interested readers may want to peruse the book chapters to assess relevance to their personal interests. I regard this impressive text as a ''must have'' in the medical libraries of most hospitals. Clinicians and researchers with an interest in vitamin D may want their own personal copy for ready reference. I highly recommend it and congratulate the authors and editors in providing a much needed reference text on arguably one of the more important nutrients to our species."-- American Journal of Human Biology

"In this remarkable compendium, the editors provide a fresh and comprehensive review of a multifaceted and sometimes controversial vitamin D. This third edition is not just an update, but a greatly expanded work organized to authoritatively cover the evidence for new roles of vitamin D in cardiovascular health, immunity, psychiatric disorders, and much more. In more than 100 chapters, experts span the history of vitamin D, update its molecular mechanism and chemistry, provide specifics of clinical use in disorders of the skeleton, and review progress in an array of diseases including diabetes, inflammatory bowel disease, multiple sclerosis, and psoriasis. In this edition one finds new information for a broad audience including internal medicine, nutrition, orthopedics, basic scientists, and teachers. How does one define optimal vitamin D status? How does vitamin D affect innate immunity? What are the epigenetic modifications of the vitamin D receptor that contribute to its function? Are there other natural ligands for the vitamin D receptor? These are a part of the new increased scope of Vitamin D, Third Edition . If you are interested in vitamin D, you should have this book."

-Mark S. Nanes, MD, PhD, Professor of Medicine, Emory University, Atlanta, GA, USA

"The Third Edition of the classic text Vitamin D is a superb summary of an important and topical issue. Its contributors are truly experts in the field and they have managed to comprehensively describe the biochemistry, pharmacology and effects of vitamin D as well as to eloquently weave in the relevant biology of bone, muscle, immunology and other relevant tissues. The 105 readable chapters offer a complete and well balanced mix of basic and clinical topics that provides an opportunity to understand the full breadth of vitamin D action. Each section represents an excellent summary of up-to-date information and, as a whole, this text offers an outstanding resource that will appeal to a broad spectrum of readers - from students to established clinicians and investigators."

-Eric Orwoll, MD, Department of Medicine, Division of Endocrinology, Diabetes, and Clinical Nutrition, Oregon Health and Science University, Portland, OR, USA

"The Third Edition of Vitamin D is well written, comprehensive and balanced. Several of the new chapters, such as Epigenetic Modifications and Wnt/ß-Catenin Signaling, have strayed away from the "traditional" vitamin D but the authors have put these topics very clearly into perspective in ways that will be valuable to those studying vitamin D action. The overall list of authors for this book is a virtual '"who's who" of vitamin D research, and the coverage of the topic is appropriately broad, including those matters in nutrition and epidemiology that have been the subject of much interest in recent years."

-T. Jack Martin, AO MD DSC FRACP FRCPA FAA FRS, John Holt Fellow, Emeritus Professor of Medicine Bone, Joint & Cancer Unit, St Vincent's Institute, Victoria, Australia

Dettagli sul prodotto

• Autori: David (EDT)/ Pike Feldman
• Con la collaborazione di: John S. Adams (Editore), David Feldman (Editore), J. Wesley Pike (Editore)
• Editore: Academic Press London
• Lingue: Inglese
• Formato: Copertina rigida
• Pubblicazione: 01.06.2011, ritardato
• EAN: 9780123819789
• ISBN: 978-0-12-381978-9
• Pagine: 1952
• Categoria: Scienze naturali, medicina, informatica, tecnica > Medicina