Ulteriori informazioni
Informationen zum Autor Adrian R. Krainer! Cold Spring Harbor Laboratory! PO Box 100! 1 Bungtown Road! Cold Spring Harbor! NY 11724-2208! USA. Tel: 001 516 367 8417. Fax: 001 516 367 8453. Email: krainer@cshl.org Klappentext The control of gene expression occurs at many levels! including transcription! RNA maturation! and translation. Eukaryotic messenger RNA's undergo a variety of complex processing reactions! each one essential for gene expression and its proper regulation. This volume focuses on the majormRNA maturation reactions! primarily those that take place in the nucleus of eukaryotic cells. Topics include: the assembly of newly synthesized nuclear mRNA transcripts into hnRNP particles and catalyically active spliceosomes; the structure and mechanism of action of small nuclearribonucleoprotein particles and protein factors that catalyze pre-mRNA splicing in mammalian cells and in yeast; the regulation of gene expression and generation of protein isoform diversity by alternative splicing; the mechanisms of 3' end cleavage and polyadenylation; the architecture of the cellnucleus in relation to these processes and to the localization of the relevant substrates and factors; the diverse mechanisms of RNA processing by ribozymes and theior potential relevance for nuclear mRNA processing; the mechanisms of pliced-leader addition by trans-splicing in nematodes andtryanosomes; and the process of insertion/deletion mRNA editing in kinetoplasmid protozoa. Leading researchers provide detailed critical reviews of the history! experimental approaches! major advances! current models! and future directions for these areas of research. New students to mRNA inparticular will find it useful and inspiring. Zusammenfassung This text includes chapters on: RNA catalysed RNA processing; nuclear organization of pre-mRNA splicing factors and substrates; trans-splicing; and mRNA editing. It is intended for postgraduates! post-doctoral researchers! and academic staff in eukaryotic molecular biology. ...
