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Nuclear magnetic resonance spectroscopy is presently going through an explosive phase of development. This has been brought about largely on account of the advent of Fourier transform NMR spectrometers linked to powerful microcomputers which have opened up a whole new world for structural chemists and biochemists. This is exemplified by a host of publications, especially on new pulse sequences, which continue to provide new exciting modifications for recording two-dimensional NMR. Moreover, NMR is no longer confined to structural chemists but has moved firmly into the area of medicine as a powerful nondestructive body scanning technique. With this background, I felt that there was need for a text which would provide a fairly comprehensive account of the important features of 1 H- and 13C-NMR spectroscopy in one book, as well as make available an up-to-date account of recent developments of new pulse sequences, with particular reference to 2D-NMR spectroscopy. Since this book is written for students of chemistry and biochemistry as well as for biology students who have chemistry as a subsidiary, it was decided to avoid a complex mathematical treatment and to present, as far as possible without oversimplification, a qualitative account of 1 H- and 13C-NMR spectroscopy as it is today. I hope that the book satisfactorily meets these objectives.
Sommario
1 Chemical Shift in 1H-NMR Spectroscopy.- 1.1. Introduction.- 1.2. Relaxation Processes.- 1.3. Chemical Shift.- Recommended Reading.- 2 Spin-Spin Coupling 1H-NMR Spectroscopy.- 2.1. Introduction.- 2.2. Chemical and Magnetic Equivalence of Nuclei.- 2.3. Different Spin Systems.- 2.4. Factors Affecting Coupling Constants.- 2.5. Long-Range Spin-Spin Coupling.- 3 Experimental Procedures in NMR Spectroscopy.- 3.1. Pulsed Fourier Transform NMR Spectroscopy.- 3.2. Study of Dynamic Effects by NMR Spectroscopy.- 4 Chemical Shifts and Spin-Spin Couplings in 13C-NMR Spectroscopy.- 4.1. Chemical Shifts in 13C-NMR Spectroscopy.- 4.2. Couplings in 13C-NMR Spectroscopy.- 4.3. High-Resolution NMR in Solids.- Recommended Reading.- 5 Special Pulse Sequences and Two-Dimensional NMR Spectroscopy.- 5.1. Spin-Echo and Polarization Transfer.- 5.2. Carbon-Carbon Connectivity by INADEQUATE Spectra.- 5.3. Two-Dimensional NMR Spectroscopy.- 5.4. Chemical Shift Correlations Through Cross-Relaxation and Exchange.- 5.5. Two-Dimensional Heteronuclear Relayed Coherence Transfer (RCT) Spectroscopy.- 5.6. Double-Quantum Coherence.- Recommended Reading.- Appendix A Problems.- Appendix B Answers to Problems.
