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For many decades, cancer research concentrated heavily on "or ganic" aspects of the disease and ignored the role of trace elements and minerals in carcinogenesis and tumor growth. However, in recent years, spectacular progress has been made in "inorganic" cancer research: numerous inorganic substances were shown to possess car cinogenic properties. Quite unexpectedly, certain coordination compounds of platinum were found to have powerful antineoplastic properties, and a number of essential trace elements were demon strated to have profound effects on the genesis and growth of spontaneous, induced, or transplanted tumors. It therefore appeared desirable to call upon leading authorities in the field of inorganic cancer research to present their views in a conference dedicated specifically to their discipline. But since trace elements are nor mal constituents of foods, it seemed advantageous to include nutri tional aspects into the program. The fact that diet and nutrition influence tumor growth and development has been known or suspected for a long time. However, too little research has been done in this important field, resulting in a serious retardation of knowledge. Hence, this opportunity to cover nutritional aspects of cancer was taken, even though it was clear from the beginning that this broad field could not really be treated in the available time. It was necessary, for example, to exclude entirely the vast area of nutri tion as an adjuvant in cancer therapy, and even then, further limi tation of the scope of topics to be covered had to be made.
Sommario
I Carcinogenesis by Inorganic Compounds and Minerals.- 1. An Overview of Metal Carcinogenesis.- 2. Beryllium Carcinogenesis.- 3. Asbestos Carcinogenesis.- 4. Carcinogenicity of Nickel Subsulfide in Fischer Rats and Syrian Hamsters After Administration by Various Routes.- 5. The Topical Effects of Nickel Subsulfide on Renal Parenchyma.- 6. Lung. Tumor Response in Mice to Metals and Metal Salts.- 7. Occupational Cancer in Men Exposed to Metals.- 8. Infidelity of DNA Synthesis as Related to Mutagenesis and Carcinogenesis.- 9. Metals as Mutagens.- II Metal Compounds in Chemotherapy and Related Topics.- 10. Noble Metal Complexes in Cancer Chemotherapy.- 11. Potential Carcinostatic Activity of Metal Complexes.- 12. Anti-Tumor Virus Activity of Copper Binding Drugs.- 13. Reaction of Copper Complexes with Ehrlich Cells.- 14. The Inhibitory Effect of Copper on Ethionine Carcinogenesis.- III Nutrition and Trace Elements in Cancer.- 15. Diet, Nutrition, and Cancer.- 16. The Effects of Iron Deficiency and the Quality and Quantity of Fat on Chemically Induced Cancer.- 17. Implications of the Inhibition of Animal Tumors by Dietary Zinc Deficiency.- 18. The Arsenic Problems.- 19. The Influence of Nutritional Factors on Pulmonary Adenomas in Mice.- 20. Iodine and Mammary Cancer.- 21. Gastrointestinal Cancer: Epidemiology and Experimental Studies.- IV Trace Elements and Nutrition in Cancer Prevention.- 22. Trace Elements, Nutrition, and Cancer: Perspectives of Prevention.- Contributor Index.
Riassunto
For many decades, cancer research concentrated heavily on "or ganic" aspects of the disease and ignored the role of trace elements and minerals in carcinogenesis and tumor growth.
