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Even a casual search of recent literature would show that the involvement of transglutaminases in a great variety of biological reactions has captured the imagination of many investigators. The present volume of Molecular and Cellular Biochemistry is a reflection of this growing interest. Transglutaminases catalyze the post-translational modification of proteinbound glutamine residues which either causes protein cross-linking by 'Y-glutamyl-e-Iysine peptide bridges or covalent incorporation of small molecular weight amines. These reactions could have far-reaching effects on altering the physical states and biochemical behaviors of the extra-cellular or intra-cellular systems. Examples could be drawn from clotting in blood or in seminal fluid, from keratinization, from cell aging, or from cell activation. Within the framework of the definition, the transglutaminase name denotes not just a single enzyme but a large group of enzymes with distinct characteristics. Multiple forms are often found in a given tissue or cell type, but, as yet, we do not know the reasons for this diversity. Editors: Laszlo Lorand, Ph.D. Victor A. Najjar, M.D. Molecular and Cellular Biochemistry 58, 9-35 (1984). © 1984, Martinus Nijhoff Publishers, Boston. Transglutaminases Laszlo Lorand and Sylvia M. Conrad Department of Biochemistry, Molecular and Cell Biology, Northwestern University, Evanston, IL 60201, U.S.A.
Sommario
Preface.- Transglutaminases.- Detection of ?(?-glutamyl) lysine.- Transglutaminases and the clotting of mammalian seminal fluids.- Cross-linking of fibronectin to collagenous proteins.- Transglutaminase and receptor-mediated endocytosis in macrophages and cultured fibroblasts.- ?-adrenergic receptor internalization and processing: role of transglutaminase and lysosomes.- Transglutaminase catalyzed incorporation of putrescine into surface proteins of mouse neuroblastoma cells.- Epidermal and hair follicle transglutaminases and cross-linking in skin.- Transglutaminase-mediated cross-linking in mammalian epidermis.- Human ?2 macroglobulin.- Isopeptide bond formation in epidermis.
