Chemical Biology in Regenerative Medicine - Bridging Stem Cells and Future Therapies

Informationen zum Autor Dr Charles C. Hong is a physician-scientist with background in molecular biology, developmental biology, chemical biology, and cardiovascular genetics. He is an Associate Professor of Cardiovascular Medicine, Pharmacology, and Cell and Developmental Biology, and a member of the Veterans Affairs Tennessee Valley Healthcare System.? He is also a member of the Vanderbilt Institute of Chemical Biology and the Vanderbilt Center for Stem Cell Biology.?Dr. Hong received his MD-PhD with Honors from Yale, then completed cardiology fellowship at Massachusetts General Hospital, where he was a Schreyer Fellow, and postdoctoral fellowship at Harvard Medical School, where he was a Sarnoff Scholar. After a brief stint on the Harvard Medical School faculty, Dr. Hong came to Vanderbilt in 2006.?The Hong laboratory is focused on Chemical Biology of vertebrate development and stem cell differentiation, specifically Chemical Genetics of Embryonic Development; Regenerative Chemical Biology & Drug Discovery/ Experimental Therapeutics. Dr Ada S. Ao , Postdoctoral Research Fellow, Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University, USA. Prof Jijun Hao , Research Assistant Professor, Western University of Health Sciences, USA. Klappentext Chemical Biology in Regenerative Medicine: Bridging Stem Cells and Future TherapiesThe field of regenerative medicine has advanced at a rapid pace and this comprehensive summary of new developments is a timely contribution to the field as clinical trials have begun to assess the safety and efficacy of cell-based therapies.In Chemical Biology in Regenerative Medicine, an international team of experts provides an overview of progress towards clinical application in the areas of transplantation (allogenic and autologous), manipulation of niche environment and homing, and cell reprogramming (trans-differentiation and de-differentiation). The book highlights the interdisciplinary approaches undertaken to resolve current technical problems in regenerative medicine, with special attention paid to small molecules and biomaterials engineering.This volume provides an essential overview of this emerging technology for researchers in academic, industrial and clinical environments working in regenerative medicine, chemical biology, biochemistry, cell biology, biomaterials and bioengineering. It is appropriate for training students and newcomers to the field, benefitting readers in broadening their knowledge and giving them insights to regenerative chemical biology, as well as encouraging readers to implement the key points in their own fields of study to develop new technologies. Zusammenfassung The field of regenerative medicine has advanced at a rapid pace. This book highlights the interdisciplinary approaches undertaken to resolve various technical problems in regenerative medicine, with special attention paid to small molecules and biomaterials engineering. Inhaltsverzeichnis List of Contributors xi Preface xiii 1 Wnt Signaling in Regulation of Stem Cells 1 David T. Paik and Antonis K. Hatzopoulos 1.1 Overview of Wnt Signaling 1 1.2 Wnt Signaling in Embryonic Stem Cells 2 1.3 Wnt Signaling in Cardiovascular Progenitor Cells and Cardiomyocyte Differentiation 3 1.4 Wnt Signaling in Mesenchymal Stem Cells 5 1.5 Wnt Signaling in Hematopoiesis and Hematopoietic Stem Cells 7 1.6 Wnt Signaling in Neural Stem Cells 8 1.7 Wnt Signaling in Endothelial-Mesenchymal Transition 8 1.8 Conclusion 9 References 10 2 Directed Cardiomyogenesis of Pluripotent Stem Cells 15 Jeffery B. Bylund and Antonis K. Hatzopoulos 2.1 Introduction 15 2.2 A Brief Review of Heart Development 16 2.2.1 Cellular and Morphological Movements 16 2.2.2 Molecular Events in Heart Developm...

Sommario

List of Contributors xi
 
Preface xiii
 
1 Wnt Signaling in Regulation of Stem Cells 1
David T. Paik and Antonis K. Hatzopoulos
 
1.1 Overview of Wnt Signaling 1
 
1.2 Wnt Signaling in Embryonic Stem Cells 2
 
1.3 Wnt Signaling in Cardiovascular Progenitor Cells and Cardiomyocyte Differentiation 3
 
1.4 Wnt Signaling in Mesenchymal Stem Cells 5
 
1.5 Wnt Signaling in Hematopoiesis and Hematopoietic Stem Cells 7
 
1.6 Wnt Signaling in Neural Stem Cells 8
 
1.7 Wnt Signaling in Endothelial-Mesenchymal Transition 8
 
1.8 Conclusion 9
 
References 10
 
2 Directed Cardiomyogenesis of Pluripotent Stem Cells 15
Jeffery B. Bylund and Antonis K. Hatzopoulos
 
2.1 Introduction 15
 
2.2 A Brief Review of Heart Development 16
 
2.2.1 Cellular and Morphological Movements 16
 
2.2.2 Molecular Events in Heart Development 19
 
2.2.2.1 Molecular Events of Mesoderm Derivation 19
 
2.2.2.2 Transcription Factors in Cardiac Development 20
 
2.2.2.3 Major Developmental Signaling Pathways in Cardiac Development 22
 
2.3 Introduction to Pluripotent Stem Cells 23
 
2.3.1 Unique Features of Pluripotent Stem Cells 23
 
2.3.2 Pluripotent Stem Cell Sources 24
 
2.3.3 Maintaining Pluripotency 24
 
2.4 Cardiomyocyte Differentiation 25
 
2.4.1 Inducing Differentiation 25
 
2.4.2 Directed Cardiomyogenesis 26
 
2.5 Conclusion 28
 
References 29
 
3 Chemical Genetics in Cardiomyocyte Generation 35
Daqing Jin, Qiao Li, and Tao P. Zhong
 
3.1 Introduction 35
 
3.2 iPSC Generation 36
 
3.3 The Chemical Genetics Approach in iPSC Generation 37
 
3.4 Heart Regeneration 40
 
3.5 The Chemical Genetics Approach in Heart Regeneration 42
 
3.6 Cardiac Cell Transdifferentiation 43
 
3.7 Conclusion 44
 
Acknowledgements 44
 
References 44
 
4 Challenges and New Directions for Cardiac Reprogramming 49
Young-Jae Nam and Nikhil Munshi
 
4.1 Introduction 49
 
4.2 Strategies for Heart Repair 49
 
4.3 Direct Reprogramming Approaches 50
 
4.4 Current Challenges 53
 
4.5 Conclusion 56
 
Acknowledgements 56
 
References 56
 
5 Comparative Analysis of Adult Stem Cell Niches 59
Bryan A. Fioret and Antonis K. Hatzopoulos
 
5.1 Adult Stem Cells 59
 
5.2 Adult Stem Cell Niches 60
 
5.3 The Hair Follicle Stem Cell (HFSC) Niche 61
 
5.4 The Intestinal Stem Cell (ISC) Niche 63
 
5.5 The Hematopoietic Stem Cell (HSC) Niche 66
 
5.5.1 Endosteal Niche 66
 
5.5.2 Vascular Niche 67
 
5.5.3 Progeny "Niche" 68
 
5.6 The Neural Stem Cell (NSC) Niche 68
 
5.6.1 V-SVZ Niche 69
 
5.6.2 SGZ Niche 70
 
5.7 A Comparison between Tissue-Specific Adult Stem Cell Niches 71
 
5.8 Future Challenges 73
 
Acknowledgements 73
 
References 73
 
6 Chemicals and Stem Cells in the Promotion of Regeneration 77
Dikshya Bastakoty, Sarika Saraswati, and Pampee P. Young
 
6.1 Introduction 77
 
6.2 Biologics in Regenerative Medicine 78
 
6.2.1 Growth Factors and Pro-Angiogenic Agents 78
 
6.2.2 Immune-Modulatory Therapies 79
 
6.2.3 Extracellular Matrix-Based Approaches 79
 
6.3 Chemicals and Biomaterials for Healing 79
 
6.3.1 Small Molecules 80
 
6.3.2 Biomaterial Scaffold and Sustained Delivery 81
 
6.4 Stem-Cell Therapy 81
 
6.4.1 Chemical Manipulation of Stem Cells in Regeneration 82
 
6.4.2 Embryonic

Dettagli sul prodotto

• Autori: Ada Ao, Ada S Ao, Ada S. Ao, Ada S. (Department of Medicine Ao, Jijun Hao, Jijun (College of Veterinary Medicine Hao, CC Hong, Charles Hong, Charles C Hong, Charles C. Hong, Charles C. (Department of Medicine Hong, Charles C. Ao Hong
• Con la collaborazione di: Ada Ao (Editore), Ada S. Ao (Editore), Jijun Hao (Editore), Charles C. Hong (Editore)
• Editore: Wiley, John and Sons Ltd
• Lingue: Inglese
• Formato: Copertina rigida
• Pubblicazione: 22.08.2014
• EAN: 9781118349595
• ISBN: 978-1-118-34959-5
• Pagine: 240
• Categoria: Scienze naturali, medicina, informatica, tecnica > Chimica