Free Radical Mediated Injury During Coronary Artery By-pass Surgery - Time course of Free radical generation and the role of antioxidants during CABGS

Free- radicals are generated in the minutes following myocardial re-perfusion and this could be the cause of myocardial injury during by Pass surgery. Pretreatment with antioxidants could effectively attenuate re-perfusion injury during global ischemia.Xanthine dehydrogenase is converted into xanthine oxidase and this causes accumulation of hypoxanthine and xanthine in the cell. When re-perfusion starts, fresh oxygen interacts with xanthine oxidane and hypoxanthine to form superoxide anion radical O2.- . Allopurinol can metabolically block the formation of reduced oxygen radical by inhibiting the enzyme xanthine oxidase. More over allopurinal has vasodilator effects and aids in restoring favorable conditions through enhancement of collateral blood flow to the ischemic area.

Info autore

I am an Associate professor and Head of Department of Clinical Biochemistry in the Faculty of medicine at Bushehr University of Medical and Biological Sciences, Bushehr, Iran.

Dettagli sul prodotto

• Autori: Ali Movahed
• Con la collaborazione di: Teste Ashavaid (Editore), Tester Ashavaid (Editore), Netticadan (Editore), Netticadan (Editore), Thomas Netticadan (Editore)
• Editore: Scholar's Press
• Lingue: Inglese
• Formato: Tascabile
• Pubblicazione: 09.12.2013
• EAN: 9783639519907
• ISBN: 978-3-639-51990-7
• Pagine: 104
• Categoria: Scienze naturali, medicina, informatica, tecnica > Medicina