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This publication contains a collection of 22 manuscripts by authors invited to write review articles. They are based on lectures presented on the First and Second Training Course in Radiopharmacy and Radiopharmacology. These courses were organized under the auspices of the "Joint Committee on Radiopharmaceuticals" of both European Societies of Nuclear Medicine (ENMS and SNME) and were sponsored by the European Society of Nuclear Medicine (ENMS). Recent developments in radiopharmacy and radiopharmacology have been very complex; they cannot be overlooked by the medical staff in nuclear medical departments. This book has been written to provide access to recent research and to practical daily routine in patients' investigations. It provides a wide-ranging and topical overview of radiopharmacology in cluding chapters on basic chemistry and physics, incorporation dosimetry, interference of drugs in radiopharmacokinetics, legal aspects and stable isotope-labelled pharmaceuticals. Style of presentation is not uniform. Par tial overlapping concerning the content of papers has not been avoided in order to ensure different views and aspects of the same subject. We hope that the interdisciplinary approach will be stimulating and thought-provok ing for the reader. Consequently, this book is designed for specialists work ing in nuclear medical centres which involve different disciplines such as pharmacists, radiochemists, physicists, biochemists, biologists, mathemati cians, electronic engineers, physicians with different specialities, and tech nicians.
Sommario
1: Fundamentals of Radioactivity.- 2: Modern Trends in Isotope Production with Small Accelerators.- 3: Radionuclide Generator Systems.- 4: Radiopharmaceuticals: A Review.- 5: Historical Development of Radiopharmaceuticals: Bibliography.- 6: Radiopharmaceutical Agents: Recent Developments.- 7: Technetium-99m Radiopharmaceuticals: Structure-Activity-Relation-ships.- 8: Technetium-99m Radiopharmaceuticals: Their Chemical Potential and Limitations.- 9: Chemistry of Indium Complexes.- 10: Labelling and Analysis of Protein-Based Radiopharmaceuticals.- 11: Labelling of Proteins with Iodine-125 as RIA-indicators.- 12: Biological Aspects of Radiopharmacokinetics.- 13: Principles, Problems and Trends in Radiopharmacology.- 14: Basic Principles in Clinical Use of Stable Isotope Pharmaceuticals.- 15: Requirements for the Development and Evaluation of New Radiopharmaceuticals.- 16: Good Radiopharmacy Practice.- 17: Quality Control and Drug Effect.Technical Aspects of Electrophoresis, Paper and Thin-layer Chromatography, Column Chromatography.- 18: Adverse Reactions to Radiopharmaceuticals.- 19: Pharmaceutical Interaction with Radiopharmaceuticals: I. Radioiodine-, Pertechnetate Kinetics in Thyroid Endocrinology.- 20: Pharmaceutical Interaction with Radiopharmaceuticals: II. Various Labelled Compounds.- 21: Radiopharmaceuticals Toxicity and Safety.- 22: Absorbed Dose Calculations for Biologically Distributed Radiopharmaceuticals.
