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Alcoholism, the oldest addictive illness, remains a serious problem because of its major modifications of many physiological systems. The genetic and neurological origins and mechanisms are complex and only partly understood. However, it is clear that alcohol use modifies the production of most hormones, directly and indirectly modulating the systems that hormones regulate. Acute and chronic alcohol consumption affects virtually all cellular functions of tissues like brain, liver, immune system, and reproductive and endocrine organs. The latter have major regula tory roles, affecting many functions from development to repro duction. Although stress can further modify alcohol's effects on hormone production, it significantly causes most of alcohol's modi fications of the body to occur via changes in hormone production and secretion. Ronald R. Watson vii Contributors Michael L. Adams - Department of Psychiatry, Washington University School of Medicine, St. Louis, MO Robert A. Anderson, Jr .- Ob/Gyn Research, Rush-Presbyterian-St. Luke's Medical Center, Chicago,IL Kasibhatla Bhavani - Molecular Heptology Laboratory, Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA Theodore J. Cicero - Department of Psychiatry, Washington University School of Medicine, St.
Sommario
Pattern of Hormonal Response to Chronic Ethanol Ingestion During Puberty: Implication for Primary Effects on the Testicular Seminiferous Epithelium.- Opioid-Mediated Control of Neuroendocrine Function: Role of ?, ?, and ? Receptors.- Neuroendocrine Responses to Ethanol in the Prepubertal Female Rat.- Involvement of Alcohol-Metabolizing Enzymes in Retinoic Acid Synthesis and Inhibition by Ethanol.- The Effect of Ethanol on Male Rodent Reproduction and Growth.- Thyrotropin-Releasing Hormone (TRH): Clinical Neuroendocrine and Neurobehavioral Findings of Relevance to Alcoholism.- Hidden Hormones in Alcoholic Beverages: Ph ytoestrogens.- Effects of TA-0910, a Thyrotropin-Releasing Hormone Analog, on Alcohol Intake in Alcohol-Preferring Rats.- Gene Structure and Multiple Regulations of the EthanolInducible Cytochrome P4502E1 (CYP2E1) Subfamily.- Thermoregulation and Alcohol.- Alcohol and the Release of Vasopressin and Oxytocin.- Stress and Alcohol.- Effect of Ethanol on Tyrosyl Phosphorylation of Growth Factor Receptor Substrates in the Liver.- Alcohol and Reproductive Hormones in Women.- Alcohol, Opioids, and Testicular Function.- Neuromodulatory Action of Opioid Peptides on Hypothalamic Neurons.- Interactions of Alcohol and Prostaglandins.- Effect of Alcohol on Growth Hormone-Related Liver Function and Sex Hormone Homeostasis.
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