Ulteriori informazioni
The book focuses on the latest discoveries on calreticulin, calnexin and other endoplasmic reticulum proteins. Calreticulin has been implicated to affect diverse cellular function and play a role in many pathologies including protein folding disorders, cardiac pathologies, cancer and autoimmunity. This book contains contributions from the world leaders in the area of endoplasmic reticulum function, protein folding, Calcium homeostasis and autoimmunity. It raises many intriguing questions about calreticulin, calnexin and the endoplasmic reticulum and gives a unique opportunity to realize the significance of these calcium-binding chaperones. The book is unique in every respect and we are not aware of any other publication focusing on these aspects of endoplasmic reticulum biology. Because of a central role of endoplasmic reticulum, calreticulin and calnexin in virtually all cellular functions, the book should be of interest to everyone in the biological sciences.
Sommario
0.- Preface.- Abbreviations.- 1. Introduction to Calreticulin.- 2. Biochemical and Molecular Properties of Calreticulin.- 3. A Chaperone System for Glycoprotein Folding: The Calnexin/Calreticulin Cycle.- 4. Calnexin, an ER Integral Membrane Chaperone in Health and Disease.- 5. Sub-Cellular Distribution of Calreticulin.- 6. Calnexin and Calreticulin, Molecular Chaperones of the Endoplasmic Reticulum.- 7. Roles of Calreticulin and Calnexin in Myeloperoxidase Synthesis.- 9. The Role of Calnexin and Calreticulin in MHC Class I Assembly.- 10. Calreticulin and the Endoplasmic Reticulum in Plant Cell Biology.- 11. Modulation of Calcium Homeostasis by the Endoplasmic Reticulum in Health and Disease.- 12. Calnexin and Calreticulin, ER Associated Modulators of Calcium Transport in the ER.- 13. ER Calcium and ER Chaperones: New Players in Apoptosis?.- 14. Calreticulin in Cytotoxic Lymphocyte-Mediated Cytotoxicity.- 15. A Role for Calreticulin in the Clearance of Apoptotic Cells and in the Innate Immune System.- 17. Calreticulin's Role(s) in Autoimmune Disorders.- 18. Cell Surface Calreticulin: Role in Signaling Thrombospondin Anti-Adhesive Activity.- 19. Calreticulin Regulation of Lung Endothelial NOS Activity.- 20. Role of Calreticulin in Leishmania Parasite Secretory Pathway and Pathogenesis.- 21. The Hookworm Calreticulin Conundrum.- 22. Calreticulin in C. elegans.- 23. Calreticulin Deficient Mouse.- 267.- Appendix II: Amino Acid Sequence of Calreticulin.
Riassunto
The book focuses on the latest discoveries on calreticulin, calnexin and other endoplasmic reticulum proteins. Because of a central role of endoplasmic reticulum, calreticulin and calnexin in virtually all cellular functions, the book should be of interest to everyone in the biological sciences.
