COX-2 Inhibitors

COX-2 inhibitors are important drugs with analgesic and anti-inflammatory effects. The discovery of COX-2, the evolution of drug development in this field and the implications of these developments in patient therapy are topics of this volume. This book presents both pre-clinical and clinical information and is important for clinicians interested in the latest information about this class of drugs, for researchers and for students in the field.

Sommario

The discovery of COX-2.- Structural diversity of selective COX-2 inhibitors.- The molecular and biological basis for COX-2 selectivity.- Pharmacology and toxicology of COX-2 inhibitors.- Efficacy and gastrointestinal safety of selective COX-2 inhibitors.- Role of COX-2 in ulcers and ulcer healing.- COX-2 and the cardiovascular system.- Effects on the kidney: role of COX-2 inhibitors.- Effects on the lungs: role of COX-2 inhibitors.- Reproduction: role of COX-2 and its inhibition.- COX-2 in cancer.

Riassunto

COX-2 inhibitors are important drugs with analgesic and anti-inflammatory effect. The discovery of COX-2, the evolution of drug development in this field and the implications of these developments in patient therapy are topics of this volume. Animal models and clinical information are presented. The book addresses clinicians interested in the latest information about this class of drugs, researchers and students in t

Dettagli sul prodotto

• Con la collaborazione di: Miche Pairet (Editore), Michel Pairet (Editore), Joanne van Ryn (Editore), van Ryn (Editore), van Ryn (Editore)
• Editore: Springer, Basel
• Lingue: Inglese
• Formato: Tascabile
• Pubblicazione: 21.08.2013
• EAN: 9783034896078
• ISBN: 978-3-0-3489607-8
• Pagine: 250
• Dimensioni: 155 mm x 14 mm x 235 mm
• Peso: 409 g
• Illustrazioni: X, 250 p.
• Serie: Milestones in Drug Therapy; Milestones in Drug Therapy
• Categorie: Scienze naturali, medicina, informatica, tecnica > Medicina > Farmacia; B, Zellbiologie (Zytologie), Immunologie, Medical research, Immunology, Schmerz und Schmerztherapie, Medizinische Forschung, molecular biology, Pain & pain management, Pharmacology, Pain and pain management, Biomedical and Life Sciences, Cellular biology (cytology), Pain Medicine, Biomedical Research, Cell Biology, Molecular Medicine, Pharmacology/Toxicology