Anti-Cancer Drug Development

Klappentext Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided. "..this is a really extensive and comprehensive book on the drug development process. ...There is very little overlap between chapters and all are written by experts in the field. Hundreds of useful references are included for those wanting to go further. ...Very good value...and essential reading for both the scientist and Ph.D. student. Definately one for the library to stock." -Paul Loadman, University of Bradford, UK for BRITISH JOURNAL OF CANCER (2002) "Well-referenced and indexed...this text would be a useful addition to the clinic, research laboratory and institution library." - P. Parsons, Queensland Institute of Medical Research for CANCER FORUM (2002) Zusammenfassung Presents a spectrum of ideas on the development of anticancer drugs. Containing reviews of multidisciplinary fields of research! this book offers ideas on molecular targets for drug design! including signal transduction! the cell division cycle! and programmed cell death. It includes descriptions of sources for drugs and methods for testing. Inhaltsverzeichnis Contributors Preface Chapter 1 A Brief History of Cancer Chemotherapy Summary 1. Introduction 2. Genotoxic (Cytotoxic) Therapy 3. Growth Control Pathways 4. Host-Tumor Interactions 5. Conclusions References Chapter 2 Novel Targets in the Cell Cycle and Cell Cycle Checkpoints Summary 1. Introduction 2. Molecular Regulation of Cell Cycle Progression 3. Molecular Regulation of Cell Cycle Checkpoints 4. Rationale for Targeting Cyclin-Dependent Kinases and Cell Cycle Checkpoint Pathways 5. Agents and Strategies for Therapeutic Interference 6. Conclusions References Chapter 3 Growth Factor and Signal Transduction Targets for Cancer Therapy Summary 1. Introduction 2. The ErbB Family of Receptor Tyrosine Kinases (RTKs) 3. The Ras-Raf-MEK-ERK Signaling Pathway 4. c-Src Kinase, Signal Transduction, Transformation, and Cancer 5. Akt 6. Nuclear Hormone Receptors as Targets for Cancer Therapy 7. Implications for Drug Discovery and Development References Chapter 4 Cell Death Pathways as Targets for Anticancer Drugs Summary 1. Introduction 2. Two Main Pathways for Drug-Induced Apoptosis 3. Modulation of Drug-Induced Cell Death by Bcl-2 and Related Proteins 4. The Central Role of Caspases in Drug-Induced Apoptosis 5. Synergy between Death Receptors and Cytotoxic Drugs 6. The Rel/NF-kB/IkB Proteins 7. Conclusion References Chapter 5 Drug Resistance Pathways as Targets Summary 1. Introduction 2. Targeting Drug Transport 3. Targeting Cellular Stress Responses 4. Targeting DNA Repair Systems 5. Conclusions References Chapter 6 Role of Matrix Metalloproteinases and Plasminogen Activators in Cancer Invasion and Metastasis: Therapeutic Strategies Summary 1. Introduction 2. The Extracellular Matrix 3. Cancer Invasion and Metastasis 4. Cell Adhesion in Cancer 5. Cancer Cell Motility 6. Inflammatory Response to Cancer 7. Proteolytic Enzymes Implicated in Cancer Invasion 8. MMPIs as Novel Anticancer Agents 9. Sheddases 10. The uPA System: Proteolytic Control of MMP Activation References Chapter 7 Tumor Vasculature as a Target Summary 1. Introduction 2. How to Inhibit T...

Sommario

Contributors

Preface

Chapter 1 A Brief History of Cancer Chemotherapy

Summary

1. Introduction

2. Genotoxic (Cytotoxic) Therapy

3. Growth Control Pathways

4. Host-Tumor Interactions

5. Conclusions

References

Chapter 2 Novel Targets in the Cell Cycle and Cell Cycle Checkpoints

Summary

1. Introduction

2. Molecular Regulation of Cell Cycle Progression

3. Molecular Regulation of Cell Cycle Checkpoints

4. Rationale for Targeting Cyclin-Dependent Kinases and Cell Cycle Checkpoint Pathways

5. Agents and Strategies for Therapeutic Interference

6. Conclusions

References

Chapter 3 Growth Factor and Signal Transduction Targets for Cancer Therapy

Summary

1. Introduction

2. The ErbB Family of Receptor Tyrosine Kinases (RTKs)

3. The Ras-Raf-MEK-ERK Signaling Pathway

4. c-Src Kinase, Signal Transduction, Transformation, and Cancer

5. Akt

6. Nuclear Hormone Receptors as Targets for Cancer Therapy

7. Implications for Drug Discovery and Development

References

Chapter 4 Cell Death Pathways as Targets for Anticancer Drugs

Summary

1. Introduction

2. Two Main Pathways for Drug-Induced Apoptosis

3. Modulation of Drug-Induced Cell Death by Bcl-2 and Related Proteins

4. The Central Role of Caspases in Drug-Induced Apoptosis

5. Synergy between Death Receptors and Cytotoxic Drugs

6. The Rel/NF-kB/IkB Proteins

7. Conclusion

References

Chapter 5 Drug Resistance Pathways as Targets

Summary

1. Introduction

2. Targeting Drug Transport

3. Targeting Cellular Stress Responses

4. Targeting DNA Repair Systems

5. Conclusions

References

Chapter 6 Role of Matrix Metalloproteinases and Plasminogen Activators in Cancer Invasion and Metastasis: Therapeutic Strategies

Summary

1. Introduction

2. The Extracellular Matrix

3. Cancer Invasion and Metastasis

4. Cell Adhesion in Cancer

5. Cancer Cell Motility

6. Inflammatory Response to Cancer

7. Proteolytic Enzymes Implicated in Cancer Invasion

8. MMPIs as Novel Anticancer Agents

9. Sheddases

10. The uPA System: Proteolytic Control of MMP Activation

References

Chapter 7 Tumor Vasculature as a Target

Summary

1. Introduction

2. How to Inhibit Tumor Angiogenesis

3. Concluding Remarks

References

Chapter 8 Gene-Directed Enzyme Prodrug Therapy

Summary

1. Introduction

2. Background

3. Enzyme-Prodrug Systems

4. Tailored Prodrugs for GDEPT

5. The Activation Process

6. Augmenting the Effect

7. Exploiting the Bystander Effect and Acquired Immunity

8. Conclusions

References

Chapter 9 Tumor Antigens as Targets for Anticancer Drug Development

Summary

1. Introduction

2. Antigen Targets for Cancer Vaccines

3. Tumor Antigens as Targets for Antibody-Based Therapeutics

References

Chapter 10 Structure-Based Drug Design and its Contributions to Cancer Chemotherapy

Summary

1. Introduction

2. Antimetabolites

3. Protease Inhibitors

4. Protein Kinase Inhibitors

5. Other Targets

Relazione

"..this is a really extensive and comprehensive book on the drug development process. ...There is very little overlap between chapters and all are written by experts in the field. Hundreds of useful references are included for those wanting to go further. ...Very good value...and essential reading for both the scientist and Ph.D. student. Definately one for the library to stock." --Paul Loadman, University of Bradford, UK for BRITISH JOURNAL OF CANCER, 2002
"Well-referenced and indexed...this text would be a useful addition to the clinic, research laboratory and institution library." --P. Parsons, Queensland Institute of Medical Research for CANCER FORUM, 2002

Dettagli sul prodotto

• Autori: Bruce C. Kerr Baguley, David J. Kerr
• Con la collaborazione di: Bruce C Baguley (Editore), Bruce C. Baguley (Editore), Bruce C. (The University of Auckland Baguley (Editore), Baguley Bruce C. (Editore), David J Kerr (Editore), David J. Kerr (Editore), David J. (University of Oxford Kerr (Editore), Kerr David J. (Editore)
• Editore: ELSEVIER SCIENCE BV
• Lingue: Inglese
• Formato: Copertina rigida
• Pubblicazione: 17.11.2001
• EAN: 9780120726516
• ISBN: 978-0-12-072651-6
• Pagine: 397
• Categorie: Scienze naturali, medicina, informatica, tecnica > Medicina > Farmacia; Medical research, MEDICAL / Pharmacology, MEDICAL / Chemotherapy, MEDICAL / Laboratory Medicine, MEDICAL / Research, Chemotherapy, Pharmacology, Medical laboratory testing & techniques, Medical laboratory testing and techniques