Antimalarial Chemotherapy - Mechanisms of Action, Resistance, and New Directions in Drug Discovery

Philip Rosenthal, MD, and a panel of leading malaria experts drawn from academia, the military, and international health organizations survey the latest scientific understanding of antimalarial chemotherapy, emphasizing the molecular mechanisms of resistance and the description of important new targets. Their survey covers the current status of malarial and antimalarial chemotherapy, the relevant biology and biochemistry of malaria parasites, the antimalarial drugs currently available, new chemical approaches to chemotherapy, and possible new targets for chemotherapy. Comprehensive and cutting-edge, Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery clearly delineates all the basic and clinical research now addressing one of the world's major unresolved disease problems, work that is now powerfully driving the rapid pace of antimalarial drug discovery today.

Sommario

I Introduction.- 1 The Need for New Approaches to Antimalarial Chemotherapy.- 2 The History of Antimalarial Drugs.- 3 Transport and Trafficking in Plasmodium-Infected Red Cells.- 4 The Plasmodium Food Vacuole.- 5 Clinical and Public Health Implications of Antimalarial Drug Resistance.- II Established Antimalarial Drugs and Compounds Under Clinical Development.- 6 Chloroquine and Other Quinoline Antimalarials.- 7 8-Aminoquinolines.- 8 Mechanisms of Quinoline Resistance.- 9 Folate Antagonists and Mechanisms of Resistance.- 10 Artemisinin and Its Derivatives.- 11 Atovaquone-Proguanil Combination.- 12 The Antimalarial Drug Portfolio and Research Pipeline.- III New Compounds, New Approaches, and New Targets.- 13 Novel Quinoline Antimalarials.- 14 New Antimalarial Trioxanes and Endoperoxides.- 15 Antibiotics and the Plasmodial Plastid Organelle.- 16 Fresh Paradigms for Curative Antimetabolites.- 17 Iron Chelators.- 18 Protease Inhibitors.- 19 Inhibitors of Phospholipid Metabolism.- 20 Development of New Malaria Chemotherapy by Utilization of Parasite-Induced Transport.

Riassunto

Philip Rosenthal, MD, and a panel of leading malaria experts drawn from academia, the military, and international health organizations survey the latest scientific understanding of antimalarial chemotherapy, emphasizing the molecular mechanisms of resistance and the description of important new targets. Their survey covers the current status of malarial and antimalarial chemotherapy, the relevant biology and biochemistry of malaria parasites, the antimalarial drugs currently available, new chemical approaches to chemotherapy, and possible new targets for chemotherapy. Comprehensive and cutting-edge, Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery clearly delineates all the basic and clinical research now addressing one of the world's major unresolved disease problems, work that is now powerfully driving the rapid pace of antimalarial drug discovery today.

Testo aggiuntivo

"With contributions from 41 different authors, this book provides a welcome collection of short reviews covering numerous topics in antimalarial chemotherapy. ...this book will offer a useful review for those who study malaria and, more importantly, an entry point into antimalarial chemotherapy for those new in the field." - Journal of Medicinal Chemistry

"...the publication of a new on antimalarial chemotheraphy is very topcial and timely. Philip Rosenthal has put together a very comprehensive book on the current status of research in this important field of medicianl chemistry....The part on established antimalarial drugs covers all drugs currently in clinical application and trials....Special emphasis is put in many articles on aspects of toxicity, therapy, problems, and future developments....the editor has managed to compile the contributions in such a way that a comprehensive picture of the current status emerges and the book feels more like a single-author publication than an edited work....The book is a must for chemists, biologists, and health professionals involved in malaria research." - ChemBioChem

"...thought provoking with its new leads to drug discovery...an essential addition to the libraries and an essential reading book for malariologists." -The National Journal of India

Relazione

"With contributions from 41 different authors, this book provides a welcome collection of short reviews covering numerous topics in antimalarial chemotherapy. ...this book will offer a useful review for those who study malaria and, more importantly, an entry point into antimalarial chemotherapy for those new in the field." - Journal of Medicinal Chemistry

"...the publication of a new on antimalarial chemotheraphy is very topcial and timely. Philip Rosenthal has put together a very comprehensive book on the current status of research in this important field of medicianl chemistry....The part on established antimalarial drugs covers all drugs currently in clinical application and trials....Special emphasis is put in many articles on aspects of toxicity, therapy, problems, and future developments....the editor has managed to compile the contributions in such a way that a comprehensive picture of the current status emerges and the book feels more like a single-author publication than an edited work....The book is a must for chemists, biologists, and health professionals involved in malaria research." - ChemBioChem

"...thought provoking with its new leads to drug discovery...an essential addition to the libraries and an essential reading book for malariologists." -The National Journal of India

Dettagli sul prodotto

• Con la collaborazione di: Phili J Rosenthal (Editore), Philip J Rosenthal (Editore), Philip J. Rosenthal (Editore)
• Editore: Springer, Berlin
• Lingue: Inglese
• Formato: Tascabile
• Pubblicazione: 25.10.2010
• EAN: 9781617371240
• ISBN: 978-1-61737-124-0
• Pagine: 396
• Dimensioni: 178 mm x 22 mm x 254 mm
• Peso: 772 g
• Illustrazioni: XI, 396 p.
• Serie: Infectious Disease; Infectious Disease
• Categorie: Scienze naturali, medicina, informatica, tecnica > Medicina > Branche non cliniche; C, Medicine, Diseases, infectious diseases