Ulteriori informazioni
Present and potential future applications of new diagnostic
strategies basedon the direct or indirect detection of
cancer genes are delineated in this volume. Among the
methodological aspects covered are enzymatic target
amplification by the polymerase chain reaction and related
techniques, DNA fingerprinting, transfer of putative cancer
genes in appropriate receipient cells, and recent
developments inthe application of monoclonal antibodies in
immunohistochemistry and immunoscintigraphy. The diagnostic
and functional implications of mutations in cancer genes
such as ras and p53 are described. The characterization of
cancer genes and their products is correlated with growth
control anddissemination of tumour cells by in vitro or
clinical evidence. The contributions in the present volume
uptdate the information available on established or newly
described cancer genes, and may help manage the transition
from basic research to clinical practice.
Sommario
The Polymerase Chain Reaction: Methodology and Diagnostic Potential.- Gene Loss as Marker in Tumor Development: Considerations on the Origin of Specific Brain Tumors Due to Combinant Loss of Function Mutations of Tumor Suppressor Genes.- p53: Oncogene, Tumor Suppressor, or Both?.- Tumor Genome Screening by Multilocus DNA Fingerprints as Obtained by Simple Repetitive Oligonucleotide Probes.- Activation of ras Oncogenes in Human Tumours.- Laboratory Techniques in the Investigation of Human Papillomavirus Infection.- Detection of Minimal Residual Leukemia by Polymerase Chain Reactions.- A Dominant Metastogene Confers Metastatic Potential to Tumor Cells.- Progression in Human Melanoma Is Accompanied by the Altered Expression of Cell Adhesion Molecules.- Structure, Function and Expression of the CEA Gene Family: Diagnostic and Therapeutic Implications.- Membrane Proteins as Markers for Normal and Neoplastic Endocrine Cells.- Biological and Clinical Relevance of the Tumor-Associated Serine Protease uPA.- Analysis of Growth Regulatory Pathways in Human Neuro-Oncology.- HER-2/Neu/c-ERB-B2 Amplification: Clinical Relevance in Mammary Carcinoma.- Cytokine-Mediated Regulation of Growth Factor Receptors (EGF-R and erb-B2) in Pancreatic Tumors.- Chimeric CEA-Specific Antibody Fragments and Anti-idiotypic Antibodies for Immunoscintigraphy and New Therapeutic Approaches to Colorectal Carcinomas.- Tumor Localization by Immunoscintigraphy: Potential and Limitations.
Info autore
Dr. phil. Siegfried Armin Neumann, geboren 1934 in Ostpreußen, kam 1947 über Dänemark nach Mecklenburg, dort tätig in der Landwirtschaft. Nach Abitur 1953 Studium der Germanistik und Volkskunde in Rostock, 1961 Promotion in Berlin. 1957 - 1993 erst wissenschaftlicher Mitarbeiter, dann Forschungsgruppenleiter an der Deutschen Akademie der Wissenschaften in Berlin; 1994 mit gleicher Funktion Wechsel nach Göttingen. Seit 1988 Leitung des Wossidlo-Archivs in Rostock, welches ab 1991 als Institut für Volkskunde in M-V weitergeführt sowie 1999 in die Universität Rostock integriert wurde. Dort noch heute als Professor für Niederdeutsche Volkskunde tätig. Seine zahlreichen Veröffentlichungen - hauptsächlich deutsche Volksdichtung und Popularliteratur - haben ihn bekannt gemacht. Auszeichnungen u. a. 1999 mit dem Europäischen Märchenpreis und 2003 dem Johhannes-Gilhoff-Preis.
