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"Don't go to Canada" is a warning given to Dr. Phil Jones and his new wife Zena. The problem is while on their honeymoon, they end up finding themselves on the Canadian side of Niagara Falls.
While there, Phil is attacked and partially eviscerated by an unknown animal. Barely clinging to life, he receives a visit from Alan Strange who tells him of something called a longevity virus: it keeps the infected person healthy, heals wounds rapidly, and extends life indefinitely. An unfortunate side effect is periodic mad rages that cause one to take the lives of those he loves most.
During every full moon, a wolf-like animal attacks women that look similar to Zena. The police are aided in their investigation by a man who has been searching for the people infected with the virus for years. They are closing in on Phil, but can he be caught and stopped before he succeeds in killing his wife or infecting anyone else?
