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Stem Cells and CNS Development critically reviews recent findings on stem cells, their involvement in neurogenesis and gliogenesis, and the therapeutic implications of these findings. It defines by consensus the classes of stem cells in the nervous system, compares their similarities and differences, discusses the gains made in identifying human homologs of neural stem cells, and describes how these cells are beginning to be used
for therapeutic purposes. Comprehensive and cutting-edge, this book provides all developmental scientists and neurobiologists not only an authoritative account of the current results in neural stem cell research, but also an incisive review of the rapidly emerging therapeutic uses of stem cells.
Sommario
1 - Defining Neural Stem Cells and Their Role in Normal Development of the Nervous System.- 2 - Multipotent Stem Cells in the Embryonic Nervous System.- 3 - Multipotent Stem Cells in the Adult Central Nervous System.- 4 - Glial Characteristics of Adult Subventricular Zone Stem Cells.- 5 - Neuronal Restricted Precursors.- 6 - Glial Restricted Precursors.- 7 - PNS Precursor Cells.- 8 - Neural Progenitor Cells of the Adult Human Brain.- 9 - ES Cells and Neurogenesis.- 10 - Mobilizing Endogenous Stem Cells.- 11 - Transplant Therapy.- 12 - Drug Discovery and Gene Discovery.- Appendix A: Neural Stem Cell Companies.- Appendix B: Stem Cells and Transplants.- Appendix C: Patents and Stem Cells.- Appendix D: Stem Cells and US Federal Guidelines.- About the Authors.
Riassunto
Stem Cells and CNS Development critically reviews recent findings on stem cells, their involvement in neurogenesis and gliogenesis, and the therapeutic implications of these findings.
Testo aggiuntivo
"This is a surprisingly readable book. It is also very informative. Any interested clinician that wants a broad overview of the field should consult this text; so should anyone considering research in this exciting and rapidly developing field." -British Journal of Neurosurgery
Relazione
"This is a surprisingly readable book. It is also very informative. Any interested clinician that wants a broad overview of the field should consult this text; so should anyone considering research in this exciting and rapidly developing field." -British Journal of Neurosurgery
