Handbook of Neurotoxicology. Vol.II

N eurotoxicology is a broad and burgeoning field of research. Its growth in recent years can be related, in part, to increased interest in and concern with the fact that a growing number of anthropogenic agents with neurotoxic potential, including pesticides, 1ead, mercury, and the polytypic byproducts of combustion and industrial production, continue to be spewed into and accumulate in the environment. In addition, there is great interest in natural products, including toxins, as sources of therapeutic agents. Indeed, it is well known that many natural toxins ofbroadly differing structure, produced or accumulated for predatory or defensive purposes, and toxic agents, accumulated incidentalIy by numerous species, function to perturb nervous tissue. Components of some of these toxins have been shown to be useful therapeutic agents and/or research reagents. Unfor of some neurotoxicants of anthropogenic ori tunately, the environmental accumulation gin, expecialIy pesticides and metals, has resulted in incidents ofhuman poisoning, some of epidemic proportion, and high levels of morbidity and mortality. Furthermore, an increasing incidence of neurobehavioral disorders, some with baffling symptoms, is confronting clinicians. It is not clear whether this is merely the re suit of increased vigi lance and/or improved diagnostics or a consequence of improved health care. In any case, the role of exposure to environmental and occupational neurotoxicants in the etiology of these phenomena, as well as neurodegenerative diseases, is coming under increasing scrutiny and investigation.

Sommario

1 Developmental Neurotoxicology: Testing and Interpretation.- 2 Manifestations of CNS Insult During Development.- 3 Developmental Neurotoxicity: What Have We Learnedfrom Guideline Studies?.- 4 Risk Assessment of Developmental Neurotoxicants.- 5 Electrophysiologic Evidence of Neural Injury or Adaptation in Cocaine Dependence.- 6 Addictive Basis of Marijuana and Cannabinoids.- 7 Dopamine and Its Modulation of Drug-Induced Neuronal Damage.- 8 NMDA Antagonist-Induced Neurotoxicity and Psychosis: The Dissociative Stimulation Hypothesis.- 9 Emerging Drugs of Abuse: Use Patterns and Clinical Toxicity.- 10 Mechanisms of Methamphetamine-Induced Neurotoxicity.- 11 Neurotoxic Effects of Substituted Amphetamines in Rats and Mice: Challenges to the Current Dogma.- 12 Studies of Neural Degeneration Indicate that Fasciculus Retroflexus Is a Weak Link in Brain for Many Drugs of Abuse.- 13 Microsensors Detect Neuroadaptation by Cocaine: Serotonin Released in Motor Basal Ganglia Is Not Rhythmicwith Movement.- 14 Impact of Intoxication: Structural and Functional Modificationsin the Brain Induced by Ethanol Exposure.- 15 Structural and Functional Neuroimaging of the Effects of Opioids.- 16 Structural and Functional Neuroimaging of the Effects of Cocaine in Human and Nonhuman Primates.- 17 Functional Neuroimaging of Cannabinoid Effects.- 18 Neuroimaging of MDMA-Induced Neurotoxicity.- 19 Tier 1 Neurological Assessment in Regulated Animal Safety Studies.- 20 Neurological Assessment: The Role of the Clinicianin Clinical Neurotoxicology.- 21 Human Neuropsychological Testing and Evaluation.

Riassunto

N eurotoxicology is a broad and burgeoning field of research. Its growth in recent years can be related, in part, to increased interest in and concern with the fact that a growing number of anthropogenic agents with neurotoxic potential, including pesticides, 1ead, mercury, and the polytypic byproducts of combustion and industrial production, continue to be spewed into and accumulate in the environment. In addition, there is great interest in natural products, including toxins, as sources of therapeutic agents. Indeed, it is well known that many natural toxins ofbroadly differing structure, produced or accumulated for predatory or defensive purposes, and toxic agents, accumulated incidentalIy by numerous species, function to perturb nervous tissue. Components of some of these toxins have been shown to be useful therapeutic agents and/or research reagents. Unfor of some neurotoxicants of anthropogenic ori tunately, the environmental accumulation gin, expecialIy pesticides and metals, has resulted in incidents ofhuman poisoning, some of epidemic proportion, and high levels of morbidity and mortality. Furthermore, an increasing incidence of neurobehavioral disorders, some with baffling symptoms, is confronting clinicians. It is not clear whether this is merely the re suit of increased vigi lance and/or improved diagnostics or a consequence of improved health care. In any case, the role of exposure to environmental and occupational neurotoxicants in the etiology of these phenomena, as well as neurodegenerative diseases, is coming under increasing scrutiny and investigation.

Testo aggiuntivo

"This book presents a set of 21 well-chosen, up to date, reviews of a range of important topics of direct interest to neurotoxicologists in particular, but also to anyone with an interest in animal models of nervous system disease or in pathogenesis. As the title of this proposed series of volumes implies, the editors intend to cover the whole of the field, by adding further volumes in response to reader's requests - so no excuses for gaps!...The coverage is wide...It would be a pity if the emphasis on drugs of abuse put non-specialists off buying the book, because the strong mechanistic treatment of many of the chapters emphasizes the useful parallels with other, less "stimulating", neurotoxic agents. This is certainly not a book just about overdose pharmacology. " - Newsletter of the British Toxicological Society

"The Handbook of Neurotoxicology is an essential addition to the library of any serious researcher in any field of neurotoxicology and should be available in all university libraries where chemistry, biochemistry, or medical or life sciences are studied." - Journal of Natural Products

"Both volumes are laid out attractively...and contain much valuable information on the pharmacological aspects of neurotoxicology, as well as state-of-the-art methodology." Le Journal Canadien Des Sciences Neurologies

Relazione

"This book presents a set of 21 well-chosen, up to date, reviews of a range of important topics of direct interest to neurotoxicologists in particular, but also to anyone with an interest in animal models of nervous system disease or in pathogenesis. As the title of this proposed series of volumes implies, the editors intend to cover the whole of the field, by adding further volumes in response to reader's requests - so no excuses for gaps!...The coverage is wide...It would be a pity if the emphasis on drugs of abuse put non-specialists off buying the book, because the strong mechanistic treatment of many of the chapters emphasizes the useful parallels with other, less "stimulating", neurotoxic agents. This is certainly not a book just about overdose pharmacology. " - Newsletter of the British Toxicological Society

"The Handbook of Neurotoxicology is an essential addition to the library of any serious researcher in any field of neurotoxicology and should be available in all university libraries where chemistry, biochemistry, or medical or life sciences are studied." - Journal of Natural Products

"Both volumes are laid out attractively...and contain much valuable information on the pharmacological aspects of neurotoxicology, as well as state-of-the-art methodology." Le Journal Canadien Des Sciences Neurologies

Dettagli sul prodotto

• Con la collaborazione di: Edwar J Massaro (Editore), Edward J Massaro (Editore), Edward J. Massaro (Editore)
• Editore: Springer, Berlin
• Lingue: Inglese
• Formato: Tascabile
• Pubblicazione: 25.10.2010
• EAN: 9781617371943
• ISBN: 978-1-61737-194-3
• Pagine: 594
• Dimensioni: 178 mm x 33 mm x 254 mm
• Peso: 1149 g
• Illustrazioni: XVI, 594 p. 32 illus., 11 illus. in color.
• Categorie: Scienze naturali, medicina, informatica, tecnica > Medicina > Farmacia; C, neuroimaging, Lead, marijuana, Pharmacology, ZINC, psychosis, Biomedical and Life Sciences, Pharmacology/Toxicology, pesticide, neurobehavioral assessment, neurotoxicology, drugs of abuse, developmental neurotoxicology, neural degeneration